Department of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Research Center of Clinical Pharmacy, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
J Cell Mol Med. 2020 Jul;24(13):7370-7377. doi: 10.1111/jcmm.15330. Epub 2020 May 16.
This study aimed to describe the 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) status of Southeast Chinese individuals influenced by season. The secondary aim was to determine the cutoff for sufficient 25(OH)D in a four-season region. From January 2011 to June 2014, a total of 17 646 individuals were evaluated in our study. The serum levels of PTH were detected simultaneously in 5579 cases. A total of 25(OH)D and intact PTH were measured by the electrochemiluminescent immunoassay. The distribution of the concentration, prevalence and seasonal variability of 25(OH)D and PTH were studied. The mean 25(OH)D concentration in our study was 43.00(30.40) nmol/L. The prevalence of insufficiency (25(OH)D < 50 nmol/L) was 62.87% and that of deficiency (<30 nmol/L) was 28.54%. Mean serum 25(OH)D levels revealed a limited sinusoidal profile throughout the year and were significantly higher in Autumn. On the other hand, PTH levels showed an opposite response to seasonal effects relative to 25(OH)D. Age, BMI and daylight were not significantly correlated with 25(OH)D and serum PTH reached a plateau at higher values of serum 25(OH)D of 42.86 nmol/L. This study demonstrated that Vitamin D insufficiency is highly prevalent in Southeast China. The concentration of 25(OH)D in the male group was generally higher than that in the female group. Seasonal variation was an important aspect of 25(OH)D and PTH concentration. This study revealed that the optimal serum threshold of 25(OH)D for bone health should be between 40 and 50 nmol/L for Southeast Chinese individuals.
本研究旨在描述受季节影响的东南亚个体的 25-羟维生素 D（25(OH)D）和甲状旁腺激素（PTH）状况。次要目的是确定四季地区中足够的 25(OH)D 的截止值。2011 年 1 月至 2014 年 6 月，共有 17646 人在我们的研究中接受了评估。同时在 5579 例中检测了血清 PTH 水平。通过电化学发光免疫测定法测量了 25(OH)D 和完整 PTH 的浓度。研究了 25(OH)D 和 PTH 的浓度、流行率和季节性变化分布。我们研究中的平均 25(OH)D 浓度为 43.00（30.40）nmol/L。不足（25(OH)D<50 nmol/L）的患病率为 62.87%，缺乏（<30 nmol/L）的患病率为 28.54%。血清 25(OH)D 水平的平均显示出全年有限的正弦曲线特征，并且在秋季显着升高。另一方面，与 25(OH)D 相比，PTH 水平对季节性变化的反应相反。年龄、BMI 和日光与 25(OH)D 无明显相关性，血清 PTH 在血清 25(OH)D 值达到 42.86 nmol/L 的较高水平时达到平台期。本研究表明，维生素 D 不足在东南亚地区非常普遍。男性组的 25(OH)D 浓度普遍高于女性组。季节性变化是 25(OH)D 和 PTH 浓度的一个重要方面。本研究表明，对于东南亚个体，骨健康的最佳血清 25(OH)D 阈值应在 40 至 50 nmol/L 之间。
