Gupta Mayank, Abd-Elsayed Alaa, Knezevic Nebojsa Nick
Kansas Pain Management, 10995 Quivira, Overland Park, KS, 66201, USA.
University of Wisconsin, Madison, WI, USA.
Neurol Sci. 2020 Oct;41(10):2703-2710. doi: 10.1007/s10072-020-04435-0. Epub 2020 May 4.
The US government and other key stakeholders including professional medical bodies have amended recommendations in recent years to emphasize using no opioids or the lowest effective dose of opioids needed for treatment of chronic pain. However, there remains an unmet need for pain treatments that can both relieve the pain of patients and reduce the doses of opioids they require. The Center for Medicare and Medicaid Services (CMS) is currently considering such treatments through the SUPPORT ACT and has recently conferred with the Health and Human Services (HHS) Inter-agency Pain Management Task Force to consider such therapies. We reviewed literature evidence in PubMed on pain relief and opioid reduction following spinal cord stimulation (SCS) treatment. SCS presents an effective non-pharmacologic pain treatment modality that has been used for decades to reduce chronic pain from trauma or neuropathy and has been shown to either stabilize or reduce opioid use in some patients with painful conditions. A more recently developed high-frequency SCS modality, 10 kHz SCS, has the advantage of being paresthesia-independent. It has been shown to be associated with significant reductions in opioid consumption after stimulation therapy was initiated, and many patients even taking high doses of opioids (> 90 mg morphine equivalent dose per day) were able to reduce their opioid intake to levels associated with less risk. The evidence shows that reduction of opioids as early in the treatment process as possible is desirable to reduce patient risk and improve pain relief from stimulation therapy.
近年来,美国政府及包括专业医学团体在内的其他关键利益相关者修订了相关建议,以强调不使用阿片类药物或使用治疗慢性疼痛所需的最低有效剂量的阿片类药物。然而,对于既能缓解患者疼痛又能减少其所需阿片类药物剂量的疼痛治疗方法,仍存在未满足的需求。医疗保险和医疗补助服务中心(CMS)目前正在通过《SUPPORT法案》考虑此类治疗方法,并且最近已与卫生与公众服务部(HHS)跨部门疼痛管理特别工作组进行商讨,以考虑此类疗法。我们检索了PubMed上关于脊髓刺激(SCS)治疗后疼痛缓解和阿片类药物减少的文献证据。SCS是一种有效的非药物疼痛治疗方式,已被用于减轻创伤或神经病变引起的慢性疼痛数十年,并且已证明在某些疼痛患者中可稳定或减少阿片类药物的使用。一种最近开发的高频SCS模式,即10kHz SCS,具有不依赖感觉异常的优势。已证明在开始刺激治疗后,它与阿片类药物消耗量的显著减少有关,许多甚至服用高剂量阿片类药物(>90毫克吗啡当量剂量/天)的患者能够将其阿片类药物摄入量减少到与较低风险相关的水平。证据表明,尽早在治疗过程中减少阿片类药物的使用,对于降低患者风险和改善刺激治疗的疼痛缓解效果是可取的。