Baranidharan Ganesan, Bretherton Beatrice, Black Sheila
Pain Management Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Faculty of Medicine and Health, School of Medicine, University of Leeds, Leeds, UK.
Br J Pain. 2022 Aug;16(4):450-457. doi: 10.1177/20494637221084187. Epub 2022 Apr 18.
Although spinal cord stimulation (SCS) is a safe procedure, equipment-related, biological and neurological complications have been observed in previous research, particularly case reports. No reports of new neuropathic pain in the absence of neurological deficit or positive MRI findings have been described. We detail three cases of new-onset radicular pain in the L5/S1 dermatome following insertion of SCS.
This was a retrospective case series of three patients. Details of clinical background, indications for SCS and events occurring during insertion and further management were recorded.
All three cases were technically difficult and required multiple epidural entry levels, with repeated passage of the electrode into and within the epidural space. All cases involved accessing epidural space T12/L1 and L1/L2. A possible explanation for the new-onset radicular pain could concern oedema to the conus medullaris, resulting from repeated passage of the electrode at the T12/L1 level. Alternative explanations could be direct trauma to transiting nerve roots, neuroplastic changes resulting in peripheral and central sensitisation and immune-mediated nerve injury.
MRI imaging should be analysed prior to the SCS procedure to identify the level of the conus medullaris, with the aim of avoiding repeated passage of electrodes at that level. Unintended neurological adverse events should be discussed with patients during the consent process. Careful patient selection and psychological screening may also help identify patients who may be unlikely to respond to SCS therapy. Further reporting of new radiculopathic pain following SCS insertion is required to strengthen understanding of its potential causes.
尽管脊髓刺激(SCS)是一种安全的手术,但在先前的研究中,尤其是病例报告中,已观察到与设备相关、生物和神经方面的并发症。尚未有在无神经功能缺损或MRI检查结果呈阳性的情况下出现新发神经性疼痛的报告。我们详细介绍了3例在植入SCS后出现L5/S1皮节新发神经根性疼痛的病例。
这是一个对3例患者的回顾性病例系列研究。记录了临床背景细节、SCS的适应证以及植入过程中发生的事件和后续处理情况。
所有3例手术操作均有技术难度,需要多个硬膜外穿刺层次,电极需反复进入和穿过硬膜外腔。所有病例均涉及T12/L1和L1/L2硬膜外腔穿刺。新发神经根性疼痛的一个可能解释是由于电极在T12/L1水平反复通过导致脊髓圆锥水肿。其他解释可能包括对经过的神经根的直接损伤、导致外周和中枢敏化的神经可塑性变化以及免疫介导的神经损伤。
在进行SCS手术前应分析MRI影像以确定脊髓圆锥水平,目的是避免在该水平反复通过电极。在知情同意过程中应与患者讨论意外的神经不良事件。仔细的患者选择和心理筛查也可能有助于识别可能对SCS治疗无反应的患者。需要进一步报告SCS植入后新发神经根病性疼痛的情况,以加强对其潜在原因的认识。