Papakonstantinou G, Eisenhut C, Füessl H, Hehlmann R
Medizinische Poliklinik, Ludwig-Maximilians-Universität München.
Klin Wochenschr. 1988 Oct 17;66(20):1029-33. doi: 10.1007/BF01733450.
The extremely rare immunocytoma with IgD-paraproteinemia was observed in a 65-year-old man with infiltrations of the throat and the sinuses. The diagnosis was made on the basis of several biopsy specimens and serum immunoelectrophoresis. In spite of intensive chemotherapy and radiotherapy a remission was not achieved. In the final stages, a transformation into an immunoblastic sarcoma accompanied by an acute plasma-cell leukemia appeared. The patient died 11 months after diagnosis from renal failure due to infiltrations of the kidneys. The poor prognosis and the poor response to radiotherapy may be associated with the IgD-paraproteinemia. Serum electrophoresis and immunoelectrophoresis proved to be sensitive parameters for monitoring tumor recurrence.
在一名65岁患有咽喉和鼻窦浸润的男性患者中观察到极为罕见的伴有IgD副蛋白血症的免疫细胞瘤。诊断基于多个活检标本和血清免疫电泳。尽管进行了强化化疗和放疗，仍未实现缓解。在疾病晚期，发生了向免疫母细胞肉瘤的转化，并伴有急性浆细胞白血病。患者在诊断后11个月因肾脏浸润导致肾衰竭而死亡。预后不良和对放疗反应不佳可能与IgD副蛋白血症有关。血清电泳和免疫电泳被证明是监测肿瘤复发的敏感指标。
