Department of Radiology, Washington University, St. Louis, Missouri, 63110.
Department of Pathology & Immunology, Washington University, St. Louis, Missouri, 63110.
Ann Clin Transl Neurol. 2020 Jun;7(6):1055-1060. doi: 10.1002/acn3.51052. Epub 2020 May 4.
A 35-year-old man with an enhancing tumefactive brain lesion underwent biopsy, revealing inflammatory demyelination. We used quantitative Gradient-Recalled-Echo (qGRE) MRI to visualize and measure tissue damage in the lesion. Two weeks after biopsy, qGRE showed significant R2t* reduction in the left optic radiation and surrounding tissue, consistent with the histopathological and clinical findings. qGRE was repeated 6 and 14 months later, demonstrating partially recovered optic radiation R2t*, in concert with improvement of the hemianopia to ultimately involve only the lower right visual quadrant. These results support qGRE metrics as in vivo biomarkers for tissue damage and longitudinal monitoring of demyelinating disease.
一位 35 岁男性，因增强性肿块样脑部病变接受了活检，结果显示为炎症性脱髓鞘。我们使用定量梯度回波（qGRE）MRI 来可视化和测量病变组织损伤。在活检后两周，qGRE 显示左侧视辐射及其周围组织的 R2t* 值显著降低，与组织病理学和临床发现一致。6 个月和 14 个月后再次进行 qGRE，显示视辐射的 R2t* 值部分恢复，与偏盲的改善相一致，最终仅累及右下象限的视野。这些结果支持 qGRE 指标作为组织损伤的体内生物标志物和脱髓鞘疾病的纵向监测。
