• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多柔比星-氯仿 E6 载介孔硅纳米粒联合超声治疗三阴性乳腺癌的疗效。

Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer.

机构信息

Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People's Republic of China.

Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, People's Republic of China.

出版信息

Int J Nanomedicine. 2020 Apr 21;15:2659-2668. doi: 10.2147/IJN.S243037. eCollection 2020.

DOI:10.2147/IJN.S243037
PMID:32368047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7183747/
Abstract

INTRODUCTION

Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed to enhance its efficiency and overcome the side effects of chemotherapy.

MATERIALS AND METHODS

In this study, we synthesized and characterized mesoporous silica nanoparticles (MSN-DOX-Ce6) loaded with doxorubicin (DOX) and sonosensitizer, chlorin e6 (Ce6). Then, we conducted in vitro and in vivo experiments to explore the antitumor effect of MSN-DOX-Ce6 under ultrasound (US) treatment.

RESULTS

The characterization tests showed that the nanoparticles are uniformly sized spheres with mesoporous structure, resulting in a high drug-loading efficiency. In the in vitro experiments, MSN-DOX-Ce6 could effectively inhibit cell proliferation under US but not more than other treatment groups. However, the in vivo studies showed that MSN-DOX-Ce6+US has better antitumor effect than DOX+Ce6+US or DOX alone on xenograft tumor-bearing mice.

CONCLUSION

In summary, MSNs showed a great potential for DOX and Ce6 delivery. We concluded that under US, MSN-DOX-Ce6 nanocomposites increase the antitumor effect of DOX and SDT and thereby are a potential treatment for solid tumors.

摘要

简介

声动力学疗法（SDT）在实体瘤中有良好的靶向性和非侵入性优势，但抗肿瘤效果还不足以替代传统治疗。一些将 SDT 与化疗或纳米粒子结合的研究已经成功地提高了其效率，并克服了化疗的副作用。

材料和方法

在这项研究中，我们合成并表征了载有阿霉素（DOX）和声敏剂氯乙锭（Ce6）的介孔硅纳米粒子（MSN-DOX-Ce6）。然后，我们进行了体外和体内实验，以探讨超声（US）治疗下 MSN-DOX-Ce6 的抗肿瘤作用。

结果

表征测试表明，纳米粒子为具有介孔结构的均匀尺寸球体，从而实现了高载药效率。在体外实验中，MSN-DOX-Ce6 在 US 下能有效抑制细胞增殖，但不如其他治疗组。然而，体内研究表明，与 DOX+Ce6+US 或 DOX 单独治疗相比，MSN-DOX-Ce6+US 对荷瘤小鼠的肿瘤具有更好的抗肿瘤效果。

结论

总之，MSNs 显示了 DOX 和 Ce6 递送的巨大潜力。我们得出结论，在 US 下，MSN-DOX-Ce6 纳米复合材料增加了 DOX 和 SDT 的抗肿瘤效果，因此是治疗实体瘤的一种潜在方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/325128a0f615/IJN-15-2659-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/3ac331de4bcf/IJN-15-2659-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/c5a4dc3aa77b/IJN-15-2659-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/91f83607bd4e/IJN-15-2659-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/5ad5bbc68c37/IJN-15-2659-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/7217aab3b367/IJN-15-2659-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/325128a0f615/IJN-15-2659-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/3ac331de4bcf/IJN-15-2659-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/c5a4dc3aa77b/IJN-15-2659-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/91f83607bd4e/IJN-15-2659-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/5ad5bbc68c37/IJN-15-2659-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/7217aab3b367/IJN-15-2659-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1253/7183747/325128a0f615/IJN-15-2659-g0006.jpg

相似文献

1
Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer.多柔比星-氯仿 E6 载介孔硅纳米粒联合超声治疗三阴性乳腺癌的疗效。
Int J Nanomedicine. 2020 Apr 21;15:2659-2668. doi: 10.2147/IJN.S243037. eCollection 2020.
2
Multifunctional mesoporous silica nanoparticles as efficient transporters of doxorubicin and chlorin e6 for chemo-photodynamic combinatorial cancer therapy.多功能介孔二氧化硅纳米颗粒作为阿霉素和氯e6的有效转运体用于化学-光动力联合癌症治疗。
J Biomater Appl. 2018 Apr;32(9):1253-1264. doi: 10.1177/0885328218758925. Epub 2018 Feb 15.
3
Nanosonosensitizer-Augmented Sonodynamic Therapy Combined with Checkpoint Blockade for Cancer Immunotherapy.纳米声敏剂增强的声动力学疗法联合免疫检查点阻断用于癌症免疫治疗。
Int J Nanomedicine. 2021 Mar 5;16:1889-1899. doi: 10.2147/IJN.S290796. eCollection 2021.
4
Albumin-MnO gated hollow mesoporous silica nanosystem for modulating tumor hypoxia and synergetic therapy of cervical carcinoma.白蛋白-二氧化锰门控中空介孔硅纳米体系用于调节肿瘤缺氧和协同治疗宫颈癌。
Colloids Surf B Biointerfaces. 2019 Jul 1;179:250-259. doi: 10.1016/j.colsurfb.2019.03.070. Epub 2019 Apr 1.
5
Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayer-modified magnetic mesoporous silica nanocomposites.通过 pH 响应性海藻酸钠/壳聚糖多层修饰的磁性介孔硅纳米复合材料实现化学-光动力联合基因治疗和双模式癌症成像。
Biomater Sci. 2017 May 2;5(5):1001-1013. doi: 10.1039/c7bm00043j.
6
Nano-delivery vehicle based on chlorin E6, photodynamic therapy, doxorubicin chemotherapy provides targeted treatment of HER-2 negative, ανβ3-positive breast cancer.基于氯乙锭、光动力疗法、多柔比星化疗的纳米递药载体为 HER-2 阴性、αvβ3 阳性乳腺癌提供靶向治疗。
Pharmacol Res. 2020 Oct;160:105184. doi: 10.1016/j.phrs.2020.105184. Epub 2020 Sep 15.
7
Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer.载喜树碱介孔硅纳米粒靶向递药系统的构建及其体内研究
Int J Nanomedicine. 2019 Jul 9;14:5061-5071. doi: 10.2147/IJN.S202910. eCollection 2019.
8
In vivo Targeting of Liver Cancer with Tissue- and Nuclei-Specific Mesoporous Silica Nanoparticle-Based Nanocarriers in mice.在体靶向肝癌的组织和核特异性介孔硅纳米粒子为基础的纳米载体在小鼠。
Int J Nanomedicine. 2020 Oct 29;15:8383-8400. doi: 10.2147/IJN.S272495. eCollection 2020.
9
A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells.一种双功能 HER2 适体偶联、pH 激活的介孔硅纳米载体药物传递系统，为 HER2 阳性乳腺癌细胞提供体外协同细胞毒性。
Int J Nanomedicine. 2019 May 31;14:4029-4044. doi: 10.2147/IJN.S201688. eCollection 2019.
10
TPGS functionalized mesoporous silica nanoparticles for anticancer drug delivery to overcome multidrug resistance.TPGS 功能化介孔硅纳米粒子用于抗癌药物传递以克服多药耐药性。
Mater Sci Eng C Mater Biol Appl. 2018 Mar 1;84:108-117. doi: 10.1016/j.msec.2017.11.040. Epub 2017 Nov 28.

引用本文的文献

1
Therapeutic Ultrasound for Multimodal Cancer Treatment: A Spotlight on Breast Cancer.用于多模式癌症治疗的治疗性超声：聚焦乳腺癌
Annu Rev Biomed Eng. 2025 May;27(1):371-402. doi: 10.1146/annurev-bioeng-103023-111151. Epub 2025 Feb 19.
2
Theranostics Using MCM-41-Based Mesoporous Silica Nanoparticles: Integrating Magnetic Resonance Imaging and Novel Chemotherapy for Breast Cancer Treatment.基于 MCM-41 的介孔硅纳米粒子的治疗学应用：将磁共振成像与新型化疗结合用于乳腺癌治疗。
Int J Mol Sci. 2024 Jul 25;25(15):8097. doi: 10.3390/ijms25158097.
3
Nanotechnology-enabled sonodynamic therapy against malignant tumors.

本文引用的文献

1
Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy.脂质体给药系统在癌症治疗中的开发挑战和陷阱。
Semin Cancer Biol. 2021 Feb;69:337-348. doi: 10.1016/j.semcancer.2019.09.025. Epub 2019 Oct 1.
2
Sonodynamic Therapy: Advances and Challenges in Clinical Translation.声动力疗法：临床转化中的进展与挑战
J Ultrasound Med. 2019 Mar;38(3):567-580. doi: 10.1002/jum.14733. Epub 2018 Oct 19.
3
Sonodynamic therapy (SDT): a novel strategy for cancer nanotheranostics.声动力学疗法（SDT）：癌症纳米诊疗的新策略。
基于纳米技术的恶性肿瘤声动力治疗
Nanoscale Adv. 2024 Mar 26;6(8):1974-1991. doi: 10.1039/d3na00738c. eCollection 2024 Apr 16.
4
A lipid/PLGA nanocomplex to reshape tumor immune microenvironment for colon cancer therapy.一种用于重塑肿瘤免疫微环境以治疗结肠癌的脂质/聚乳酸-羟基乙酸共聚物纳米复合物。
Regen Biomater. 2024 Mar 28;11:rbae036. doi: 10.1093/rb/rbae036. eCollection 2024.
5
Preparation, Physicochemical Characterization, Antimicrobial Effects, Biocompatibility and Cytotoxicity of Co-Loaded Meropenem and Vancomycin in Mesoporous Silica Nanoparticles.美罗培南和万古霉素共载于介孔二氧化硅纳米颗粒中的制备、物理化学表征、抗菌效果、生物相容性及细胞毒性
Biomedicines. 2023 Nov 16;11(11):3075. doi: 10.3390/biomedicines11113075.
6
Bone-Targeted Nanoparticle Drug Delivery System-Mediated Macrophage Modulation for Enhanced Fracture Healing.骨靶向纳米药物递送系统介导的巨噬细胞调控增强骨折愈合。
Small. 2024 Feb;20(7):e2305336. doi: 10.1002/smll.202305336. Epub 2023 Oct 5.
7
Nanomaterials-based precision sonodynamic therapy enhancing immune checkpoint blockade: A promising strategy targeting solid tumor.基于纳米材料的精准声动力疗法增强免疫检查点阻断：一种有前景的实体瘤靶向策略。
Mater Today Bio. 2023 Sep 16;23:100796. doi: 10.1016/j.mtbio.2023.100796. eCollection 2023 Dec.
8
ROS-responsive PEGylated ferrocene polymer nanoparticles with improved stability for tumor-selective chemotherapy and imaging.具有改善稳定性的ROS响应性聚乙二醇化二茂铁聚合物纳米颗粒用于肿瘤选择性化疗和成像。
Mater Today Bio. 2023 Aug 18;22:100774. doi: 10.1016/j.mtbio.2023.100774. eCollection 2023 Oct.
9
Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment.介孔二氧化硅纳米粒子介导的乳腺癌治疗药物递送的最新进展
Pharmaceutics. 2023 Jan 9;15(1):227. doi: 10.3390/pharmaceutics15010227.
10
Single Atom-Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo-Nanodynamic Therapy of Triple Negative Breast Cancer.单原子掺杂纳米声敏剂用于三阴性乳腺癌的声/化疗协同纳米动力学治疗
Adv Sci (Weinh). 2023 Feb;10(6):e2206244. doi: 10.1002/advs.202206244. Epub 2023 Jan 16.
Sci China Life Sci. 2018 Apr;61(4):415-426. doi: 10.1007/s11427-017-9262-x. Epub 2018 Apr 2.
4
Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer.载吉西他滨的微泡用于胰腺癌的靶向化疗-声动力学治疗。
J Control Release. 2018 Jun 10;279:8-16. doi: 10.1016/j.jconrel.2018.04.018. Epub 2018 Apr 11.
5
Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy.镧系元素掺杂纳米颗粒与抗 CD33 抗体和 p53 激活肽缀合用于急性髓细胞性白血病治疗。
Biomaterials. 2018 Jun;167:132-142. doi: 10.1016/j.biomaterials.2018.03.025. Epub 2018 Mar 14.
6
Hollow MnO as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses.中空二氧化锰作为一种肿瘤微环境响应性可生物降解纳米平台用于联合治疗，有利于抗肿瘤免疫反应。
Nat Commun. 2017 Oct 12;8(1):902. doi: 10.1038/s41467-017-01050-0.
7
Artesunate Enhances the Cytotoxicity of 5-Aminolevulinic Acid-Based Sonodynamic Therapy against Mouse Mammary Tumor Cells In Vitro.青蒿琥酯增强基于5-氨基酮戊酸的声动力疗法对小鼠乳腺肿瘤细胞的体外细胞毒性。
Molecules. 2017 Mar 27;22(4):533. doi: 10.3390/molecules22040533.
8
Silicon Nanoparticles as Amplifiers of the Ultrasonic Effect in Sonodynamic Therapy.硅纳米颗粒作为声动力疗法中超声效应的放大器
Bull Exp Biol Med. 2016 Jun;161(2):296-9. doi: 10.1007/s10517-016-3399-x. Epub 2016 Jul 7.
9
5-Aminolevulinic Acid Enhances Ultrasound-mediated Antitumor Activity via Mitochondrial Oxidative Damage in Breast Cancer.5-氨基乙酰丙酸通过线粒体氧化损伤增强超声介导的乳腺癌抗肿瘤活性。
Anticancer Res. 2016 Jul;36(7):3607-12.
10
A novel and facile synthesis of porous SiO2-coated ultrasmall Se particles as a drug delivery nanoplatform for efficient synergistic treatment of cancer cells.一种新颖且简便的合成方法，用于制备多孔二氧化硅包覆的超小硒颗粒，作为一种药物递送纳米平台，用于高效协同治疗癌细胞。
Nanoscale. 2016 Apr 28;8(16):8536-41. doi: 10.1039/c6nr02298g. Epub 2016 Apr 13.