Department of Ultrasonography, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, P. R. China.
Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.
Adv Sci (Weinh). 2023 Feb;10(6):e2206244. doi: 10.1002/advs.202206244. Epub 2023 Jan 16.
Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant breast cancers, especially triple-negative breast cancer (TNBC), have evolved to acquire specific antioxidant defense functions, significantly limiting the killing efficiency of SDT. Herein, the authors have engineered a distinct single copper atom-doped titanium dioxide (Cu/TiO ) nanosonosensitizer with highly catalytic and sonosensitive activities for synergistic chemodynamic and sonodynamic treatment of TNBC. The single-atom Cu is anchored on the most stable Ti vacancies of hollow TiO sonosensitizers, which not only substantially improved the catalytic activity of Cu-mediated Fenton-like reaction, but also considerably augmented the sonodynamic efficiency of TiO by facilitating the separation of electrons (e ) and holes (h ). Both the in vitro and in vivo studies demonstrate that the engineered single atom-doped nanosonosensitizers effectively achieved the significantly inhibitory effect of TNBC, providing a therapeutic paradigm for non-invasive and safe tumor elimination through the mutual process of sono/chemo-nanodynamic therapy based on multifunctional single-atom nanosonosensitizers.
声动力学疗法（SDT）是一种有前途的治疗乳腺癌的方法，它依赖于大量活性氧（ROS）的产生来诱导氧化应激损伤。然而，突变型乳腺癌，特别是三阴性乳腺癌（TNBC），已经进化到获得特定的抗氧化防御功能，这显著限制了 SDT 的杀伤效率。在这里，作者设计了一种独特的单铜原子掺杂的二氧化钛（Cu/TiO ）纳米声敏剂，具有高催化和超声敏感性，用于协同化学动力学和声动力学治疗 TNBC。单原子 Cu 锚定在中空 TiO 声敏剂的最稳定 Ti 空位上，这不仅极大地提高了 Cu 介导的类芬顿反应的催化活性，而且通过促进电子（e ）和空穴（h ）的分离，大大提高了 TiO 的声动力学效率。体外和体内研究均表明，所设计的单原子掺杂纳米声敏剂能够有效地抑制 TNBC，为通过基于多功能单原子纳米声敏剂的声/化疗-纳米动力疗法的相互作用过程实现非侵入性和安全的肿瘤消除提供了一种治疗范例。
