Boiko Anastasiia S, Mednova Irina A, Kornetova Elena G, Bokhan Nikolay A, Semke Arkadiy V, Loonen Anton J M, Ivanova Svetlana A
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation.
Hospital, Siberian State Medical University, Tomsk, Russian Federation.
Neuropsychiatr Dis Treat. 2020 Apr 22;16:1051-1058. doi: 10.2147/NDT.S247161. eCollection 2020.
Both dehydroepiandrosterone (DHEAS) and cortisol are secreted by the adrenal glands and may modulate metabolic syndrome (MetS), which often affects the health of patients with schizophrenia. The relationship between the serum levels of these hormones and MetS has not been established.
In this pilot study, we investigated the serum levels in schizophrenia patients with and without MetS and compared them with those in healthy volunteers.
After obtaining informed consent, 110 patients with acute paranoid schizophrenia were recruited directly after admission to the Mental Health Research Institute. The control group consisted of 51 persons reported on questioning to be mentally and somatically healthy. Blood samples to prepare serum were drawn after an 8-h overnight fast during one of the first days of admission. Serum cortisol and DHEAS concentrations were quantified by enzyme-linked immunosorbent assay.
A total of 42 patients had MetS and 68 patients were without MetS. The cortisol blood level was significantly (p = 0.012) higher in schizophrenia patients without MetS in comparison to healthy controls, while patients with schizophrenia and a MetS have significantly (p = 0.014) lower DHEAS levels than healthy volunteers. These differences could, however, exclusively be attributed to female participants. Analysis of covariance adjusted for gender and age demonstrated a significant relationship between age and DHEAS levels (F = 9.512, р = 0.003).
Lower DHEAS serum levels in relationship to MetS become evident in women, but not in men, and have age differences as a confounding factor.
脱氢表雄酮（DHEAS）和皮质醇均由肾上腺分泌，可能对代谢综合征（MetS）产生调节作用，而代谢综合征常影响精神分裂症患者的健康。这些激素的血清水平与代谢综合征之间的关系尚未明确。
在这项初步研究中，我们调查了伴有和不伴有代谢综合征的精神分裂症患者的血清水平，并将其与健康志愿者的血清水平进行比较。
获得知情同意后，110例急性偏执型精神分裂症患者在入住精神卫生研究所后直接被招募。对照组由51名经询问身心健康的人组成。在入院首日的某天，经过8小时过夜禁食后采集制备血清的血样。采用酶联免疫吸附测定法定量血清皮质醇和DHEAS浓度。
共有42例患者患有代谢综合征，68例患者未患代谢综合征。与健康对照组相比，不伴有代谢综合征的精神分裂症患者的皮质醇血水平显著升高（p = 0.012），而患有代谢综合征的精神分裂症患者的DHEAS水平显著低于健康志愿者（p = 0.014）。然而，这些差异仅可归因于女性参与者。经性别和年龄校正的协方差分析显示年龄与DHEAS水平之间存在显著关系（F = 9.512，р = 0.003）。
与代谢综合征相关的较低DHEAS血清水平在女性中明显，但在男性中不明显，且年龄差异是一个混杂因素。
