Dong D Y, Sheng Z Y
Trauma Centre, Postgraduate College of PLA, Beijing, China.
J Biomed Eng. 1988 Oct;10(5):406-10. doi: 10.1016/0141-5425(88)90143-4.
The aim of this study was to develop a porous silastic tube with filmy wall acting as permanent artificial tendon. Twelve mongrel dogs were used. Peronaeus longus and tibialis anticus were exposed, divided in two places, and sutured in situ; they were then covered by the silastic tube. A dog was sacrificed after 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, and 44 weeks; specimens were removed. Each preparation was studied as follows: (i) gross observation and light microscopy for tendon preparations and (ii) transmission electron microscopy, scanning electron microscopy and phase microscopy for the pseudosheath. Our study showed that healing of the tendon was mainly an extrinsic mechanism and that the pseudosheath formed by the silastic tube can prevent the adhesion of the surrounding tissue; it follows that the use of an artificial tendon, including a tendon-graft coated with a silastic tube, in reconstruction of the flexor digital tendon in the hand is a feasible procedure. The appropriate porous diameter and porous distance should be studied further. Tendon gliding depends mainly upon the gliding plane between the composite body of the tendon and the loose connective tissue around it.
本研究的目的是研制一种具有薄膜壁的多孔硅橡胶管作为永久性人工肌腱。使用了12只杂种犬。暴露腓骨长肌和胫骨前肌，在两处切断，原位缝合；然后用硅橡胶管覆盖。分别在1、2、4、6、8、10、12、16、20、24和44周后处死一只犬，取出标本。对每个标本进行如下研究：(i) 对肌腱标本进行大体观察和光学显微镜检查，(ii) 对假鞘进行透射电子显微镜、扫描电子显微镜和相差显微镜检查。我们的研究表明，肌腱的愈合主要是一种外在机制，硅橡胶管形成的假鞘可以防止周围组织的粘连；由此可见，在手部屈指肌腱重建中使用人工肌腱，包括涂有硅橡胶管的肌腱移植物，是一种可行的方法。合适的孔径和孔距应进一步研究。肌腱滑动主要取决于肌腱复合体与其周围疏松结缔组织之间的滑动平面。
