Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Talas, 38030, Kayseri, Turkey.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Basibuyuk, 34854, Istanbul, Turkey.
Mini Rev Med Chem. 2020;20(13):1300-1310. doi: 10.2174/1389557520666200505124922.
This review explains the effects of naproxen and the naproxen moiety in important biological activities. Naproxen, 2-(6-methoxynaphthalen-2-yl)propionic acid, is one of the most utilized propionic acid derivatives to the cure of many injuries or pains. Naproxen is a non-steroidal antiinflammatory drug (NSAID), which is generally used among the NSAIDs. Even though it has gastrointestinal side effects, naproxen has been safely used for many years because of the good cardiovascular sight. In the past years, except for anti-inflammatory effects, other pharmacological activities of naproxen, especially anticancer and antimicrobial activities, gain the attention of researchers. Naproxen shows its activity by inhibiting the COX-2 enzyme. There is significant interest in the possibility that COX-2 inhibitors might retard or prevent the development of various cancer types, which is often characterized by COX-2 expression. The activities of both naproxen and new molecules derived from naproxen were frequently investigated.
这篇综述解释了萘普生及其萘普生部分在重要生物活性中的作用。萘普生，2-（6-甲氧基萘-2-基）丙酸，是用于治疗许多损伤或疼痛的最常用丙酸衍生物之一。萘普生是一种非甾体抗炎药（NSAID），通常在 NSAID 中使用。尽管它有胃肠道副作用，但由于心血管状况良好，萘普生已安全使用多年。在过去的几年中，除了抗炎作用外，萘普生的其他药理活性，特别是抗癌和抗菌活性，引起了研究人员的关注。萘普生通过抑制 COX-2 酶发挥其活性。COX-2 抑制剂可能延缓或阻止各种癌症类型的发展，这通常以 COX-2 表达为特征，这种可能性引起了极大的关注。萘普生及其衍生自萘普生的新分子的活性经常被研究。
