Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Bioorg Chem. 2019 Nov;92:103224. doi: 10.1016/j.bioorg.2019.103224. Epub 2019 Aug 27.
NSAIDs displayed chemopreventive and anticancer effects against several types of cancers. Moreover, combination of NSAIDs with anticancer agents resulted in enhanced anticancer activity. These findings have attracted much attention of researchers working in this field. The 2-arylpropionic acid-derived NSAIDs represent one of the most widely used anti-inflammatory agents. Additionally, they displayed antiproliferative activities against different types of cancer cells. Large volume of research was performed to identify molecular targets responsible for this activity. However, the exact mechanism underlying the anticancer activity of profens is still unclear. In this review article, the anticancer potential, structure activity relationship and synthesis of selected profen derivatives were summarized. This review is focused also on non-COX targets which can mediate the anticancer activity of this derivatives. The data in this review highlighted profens as promising lead compounds in future research to develop potent and safe anticancer agents.
非甾体抗炎药（NSAIDs）对多种类型的癌症表现出化学预防和抗癌作用。此外，将 NSAIDs 与抗癌药物联合使用可增强抗癌活性。这些发现引起了该领域研究人员的极大关注。2-芳基丙酸衍生的 NSAIDs 是最广泛使用的抗炎药之一。此外，它们对不同类型的癌细胞表现出抗增殖活性。大量研究旨在确定负责这种活性的分子靶标。然而，普芬的抗癌活性的确切机制尚不清楚。在这篇综述文章中，总结了选定普芬衍生物的抗癌潜力、构效关系和合成。本综述还侧重于可以介导这些衍生物抗癌活性的非 COX 靶标。本文中的数据强调了普芬作为有前途的先导化合物，可用于未来的研究，以开发有效且安全的抗癌药物。
