通过钯催化的 2-羟基苯乙酮与芳基溴的α-芳基化-氧化反应合成不对称二苯甲酮。
Synthesis of unsymmetrical benzils via palladium-catalysed α-arylation-oxidation of 2-hydroxyacetophenones with aryl bromides.
机构信息
Department of Applied Chemistry, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
出版信息
Org Biomol Chem. 2020 May 20;18(19):3679-3683. doi: 10.1039/d0ob00575d.
PMID:32369074
Abstract
A diverse set of unsymmetrically substituted benzils were facilely synthesised by a cross-coupling reaction between 2-hydroxyacetophenones and aryl bromides in the presence of a palladium catalyst. Experimental studies suggested a reaction mechanism involving a one-pot tandem palladium-catalysed α-arylation and oxidation, where aryl bromides play a dual role as mild oxidants as well as arylating agents.
摘要
通过在钯催化剂存在下，2-羟基苯乙酮与芳基溴化物之间的交叉偶联反应，可简便地合成一组不同取代的不对称二苯甲酮。实验研究表明，该反应涉及一锅串联钯催化的α-芳基化和氧化反应，其中芳基溴化物同时起到温和氧化剂和芳基化试剂的双重作用。
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