Mao Jianyou, Eberle Kelly, Zhang Jiadi, Rodriguez Carles, Xi Zhenfeng, Pericàs Miquel A, Walsh Patrick J
Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100193, P. R. China ; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Tetrahedron Lett. 2015 Jun 3;56(23):3604-3607. doi: 10.1016/j.tetlet.2015.01.189.
A tandem arylation/oxidation of diarylmethanes for the convenient synthesis of unsymmetrical triarylmethanols bearing different aryl and heteroaryl groups is described. A Pd(OAc)-NiXantphos catalyst system efficiently catalyzed arylation of weakly acidic sp-hybridized C-H bonds of diarylmethanes with aryl bromides, and the arylation products were then oxidized in situ to carbinols by simply opening the reaction flasks to air. The triarylmethanol products were obtained in 35-98% yield.
本文描述了一种通过二芳基甲烷的串联芳基化/氧化反应，便捷合成带有不同芳基和杂芳基的不对称三芳基甲醇的方法。Pd(OAc)-NiXantphos催化剂体系能有效催化二芳基甲烷中弱酸性sp杂化C-H键与芳基溴的芳基化反应，然后通过简单地打开反应瓶让空气进入，使芳基化产物原位氧化为甲醇。三芳基甲醇产物的产率为35 - 98%。
