Department of Pathophysiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.
Clinical Department of Cardiac Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, Centre of Postgraduate Medical Education, Warsaw, Poland.
Thromb Haemost. 2020 May;120(5):815-822. doi: 10.1055/s-0040-1708878. Epub 2020 May 5.
The association between blood levels of protein Z (PZ) and risk of ischemic stroke remains poorly understood. We aimed to assess this potential relationship through a meta-analysis of case-control studies. PubMed, Scopus, Web of Science Core Collection, and the Cochrane Library were searched from April 1984 to April 2019. We selected case-control studies comparing PZ levels in adult patients with ischemic stroke and controls without ischemic stroke. Six case-control studies, with a total of 1,011 ischemic stroke patients and 1,128 controls, were included. Patients in the acute phase of ischemic stroke showed significantly higher levels of PZ compared with patients in the convalescent phase (standardized mean difference [SMD]: 0.289 mg/L; 95% confidence interval [CI]: 0.010, 0.569; = 0.043). No significant differences in PZ levels were found between patients and controls in the acute phase (SMD: -0.059 mg/L; 95% CI: -0.570, 0.452; = 0.821) or in the convalescent phase of ischemic stroke (SMD: -0.341 mg/L; 95% CI: -0.736, 0.055; = 0.091). Subgroup analysis indicated that older patients (≥ 50 years old) had lower PZ levels than similarly aged controls. In contrast, when the study groups came from the United States and Australia or Europe no significant differences in PZ levels existed between patients and controls. No association between PZ and ischemic stroke was identified in this meta-analysis. The acute phase of ischemic stroke was associated with higher levels of PZ.
蛋白质 Z（PZ）与缺血性脑卒中风险之间的关联仍未被充分理解。我们旨在通过对病例对照研究的荟萃分析来评估这种潜在的关系。我们检索了 PubMed、Scopus、Web of Science Core Collection 和 Cochrane Library，检索时间从 1984 年 4 月到 2019 年 4 月。我们选择了比较成人缺血性脑卒中患者和无缺血性脑卒中对照者 PZ 水平的病例对照研究。共纳入 6 项病例对照研究，总计 1011 例缺血性脑卒中患者和 1128 例对照者。与恢复期患者相比，缺血性脑卒中急性期患者的 PZ 水平显著升高（标准化均数差 [SMD]：0.289mg/L；95%置信区间 [CI]：0.010，0.569； = 0.043）。在急性期（SMD：-0.059mg/L；95% CI：-0.570，0.452； = 0.821）或缺血性脑卒中恢复期（SMD：-0.341mg/L；95% CI：-0.736，0.055； = 0.091），患者与对照者之间的 PZ 水平无显著差异。亚组分析表明，年龄≥50 岁的患者的 PZ 水平低于同年龄对照者。相比之下，当研究组来自美国和澳大利亚或欧洲时，患者与对照者之间的 PZ 水平无显著差异。本荟萃分析未发现 PZ 与缺血性脑卒中之间存在关联。缺血性脑卒中急性期与较高的 PZ 水平相关。
