Hasenau C, Clasen B P, Roettger D
Univ.-Hals-Nasen-Ohrenklinik und Poliklinik rechts der Isar (TU) München.
Laryngol Rhinol Otol (Stuttg). 1988 Nov;67(11):576-9.
Aseptic mucositis is a regularly occurring complication during radiochemotherapy of head and neck cancer. In case of a superinfection with pathogenic microorganisms the degree of mucositits can make an interruption of cancer therapy imperative. It may also cause severe complications such as fulminating fatal infection, local spreading to the oesophagus and even mediastinitis as well as disseminated fungal infections. We investigated the effect of the systematic local combined application of H202, povidone iodine, nystatine and dexpanthenol solution for the prophylaxis and therapy of mucositis induced by radiochemotherapy. During 16 months of application of our scheme symptoms of mucositis appeared only to a minor extent. No interruption of radiochemotherapy was necessary at any time.
无菌性粘膜炎是头颈癌放化疗期间经常出现的并发症。如果发生致病微生物的二重感染，粘膜炎的程度可能使癌症治疗不得不中断。它还可能导致严重并发症，如暴发性致命感染、局部扩散至食管甚至纵隔炎以及播散性真菌感染。我们研究了系统局部联合应用过氧化氢、聚维酮碘、制霉菌素和泛醇溶液对放化疗引起的粘膜炎的预防和治疗效果。在应用我们方案的16个月期间，粘膜炎症状仅轻微出现。在任何时候都无需中断放化疗。
