Aziz Nur, Hong Yo Han, Jo Minkyeong, Kim Jin Kyeong, Kim Kyung-Hee, Ashktorab Hassan, Smoot Duane T, Hur Hoon, Yoo Byong Chul, Cho And Jae Youl
Department of Integrative Biotechnology, Sungkyunkwan University, and Biomedical Institute for Convergence at SKKU (BICS), Suwon 16419, Korea.
Proteomic Analysis Team, Research Institute, National Cancer Center, Goyang 10408, Korea.
Cancers (Basel). 2020 May 2;12(5):1141. doi: 10.3390/cancers12051141.
The gene and its encoded protein MYC-induced nuclear antigen (MINA53) are associated with multiple cancers. Besides having both an oncogenic and tumor suppressor function, the intricate role of in cancer is complex as it depends on the cancer type. In particular, the functional role of /MINA53 in gastric cancer has been poorly understood. In this study, we have unraveled the molecular signatures and functional roles of /MINA53 in gastric cancer by multiple approaches, i.e., multi-omics bioinformatics study, analysis of human gastric cancer tissues, and studies in vitro using knockdown or overexpression strategies in gastric cancer cell lines. The results indicated that the gene and MINA53 protein are commonly overexpressed in cancer patients. JMJD10/MINA53 is involved in the regulation of proliferation and survival of gastric cancer by controlling cell cycle gene expression. These processes are highly associated with MINA53 enzymatic activity in the regulation of H3K9me3 methylation status and controlling activation of AP-1 signaling pathways. This highlights the oncogenic role of /MINA53 in gastric cancer and opens the opportunity to develop therapeutic targeting of /MINA53 in gastric cancer.
该基因及其编码蛋白MYC诱导核抗原（MINA53）与多种癌症相关。除了具有致癌和肿瘤抑制功能外，其在癌症中的复杂作用还很复杂，因为这取决于癌症类型。特别是，/MINA53在胃癌中的功能作用尚未得到充分了解。在本研究中，我们通过多种方法揭示了/MINA53在胃癌中的分子特征和功能作用，即多组学生物信息学研究、人胃癌组织分析以及在胃癌细胞系中使用敲低或过表达策略进行的体外研究。结果表明，该基因和MINA53蛋白在癌症患者中普遍过表达。JMJD10/MINA53通过控制细胞周期基因表达参与胃癌增殖和存活的调节。这些过程与MINA53在调节H3K9me3甲基化状态和控制AP-1信号通路激活中的酶活性高度相关。这突出了/MINA53在胃癌中的致癌作用，并为开发针对胃癌中/MINA53的治疗靶点提供了机会。
