Mabrouk Nesrine, Ghione Silvia, Laurens Véronique, Plenchette Stéphanie, Bettaieb Ali, Paul Catherine
Laboratory of Immunology and Immunotherapy of Cancers, EPHE, PSL Research University, 75000 Paris, France.
Laboratory of Immunology and Immunotherapy of Cancers (LIIC), EA7269, University of Burgundy Franche-Comté, 21000 Dijon, France.
Cancers (Basel). 2020 May 2;12(5):1145. doi: 10.3390/cancers12051145.
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.
细胞衰老 是一种参与诸如与年龄相关疾病和癌症等生理和病理过程的细胞状态。虽然衰老机制目前已为人熟知，但其在肿瘤发生中的作用仍然极具争议。衰老对肿瘤发生的正负效应很大程度上取决于衰老表型的多样性，更确切地说，取决于衰老相关分泌表型（SASP）。在本综述中，我们讨论了一氧化氮（NO）对SASP的调节作用以及在癌症治疗中使用NO供体或诱导型一氧化氮合酶（iNOS）诱导剂联合衰老疗法可能带来的益处。
