Skretowicz J, Polakowski P, Jeromin L, Zasada M, Szymańska J, Krajewska B
Zakładu Farmakologii Katedry Farmakologii AM w Lodzi Kierownik.
Med Pr. 1988;39(4):241-5.
In 23 patients affected by urinary bladder cancer and 22 healthy volunteers, acetylation phenotype was determined in urine, using the Eidus technique involving isoniazid. In the healthy group 10 (45.4%) slow acetylators and 9 (40.9%) fast acetylators were found. Of 23 patients with the bladder cancer 14 (60.9%) were slow acetylators, whereas 5 (21.7%) exhibited fast acetylation phenotype. The studies demonstrate that among the bladder-cancer-affected patients those with slow acetylation phenotype predominates. In those of the affected patients who had been exposed to chemical substances in the past, the percentage of slow acetylators was still higher (62.5%).
在23例膀胱癌患者和22名健康志愿者中，采用涉及异烟肼的艾idus技术测定尿液中的乙酰化表型。在健康组中，发现10例（45.4%）慢乙酰化者和9例（40.9%）快乙酰化者。23例膀胱癌患者中，14例（60.9%）为慢乙酰化者，而5例（21.7%）表现为快乙酰化表型。研究表明，在受膀胱癌影响的患者中，慢乙酰化表型者占主导。在过去接触过化学物质的受影响患者中，慢乙酰化者的比例仍然更高（62.5%）。
