Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Cell Commun Signal. 2020 May 5;18(1):71. doi: 10.1186/s12964-020-00542-9.
Efferocytosis is a physiologic phagocytic clearance of apoptotic cells, which modulates inflammatory responses and the immune environment and subsequently facilitates immune escape of cancer cells, thus promoting tumor development and progression. Efferocytosis is an equilibrium formed by perfect coordination among "find-me", "eat-me" and "don't-eat-me" signals. These signaling pathways not only affect the proliferation, invasion, metastasis, and angiogenesis of tumor cells but also regulate adaptive responses and drug resistance to antitumor therapies. Therefore, efferocytosis-related molecules and pathways are potential targets for antitumor therapy. Besides, supplementing conventional chemotherapy, radiotherapy and other immunotherapies with efferocytosis-targeted therapy could enhance the therapeutic efficacy, reduce off-target toxicity, and promote patient outcome. Video abstract.
吞噬作用是一种生理性的吞噬清除凋亡细胞的过程，它调节炎症反应和免疫环境，从而促进癌细胞的免疫逃逸，进而促进肿瘤的发展和进展。吞噬作用是由“找我”、“吃我”和“别吃我”信号之间的完美协调形成的平衡。这些信号通路不仅影响肿瘤细胞的增殖、侵袭、转移和血管生成，还调节抗肿瘤治疗的适应性反应和耐药性。因此，吞噬作用相关的分子和途径是抗肿瘤治疗的潜在靶点。此外，将吞噬作用靶向治疗与传统的化疗、放疗和其他免疫疗法相结合，可以增强治疗效果，降低脱靶毒性，改善患者的预后。视频摘要。
