School of Psychology, University of Newcastle, University Drive, Callaghan, NSW, Australia, 2308.
School of Psychology, University of Newcastle, University Drive, Callaghan, NSW, Australia, 2308.
Hear Res. 2021 Jan;399:107975. doi: 10.1016/j.heares.2020.107975. Epub 2020 Apr 23.
The concept of perceptual inferences taking place over multiple timescales simultaneously raises questions about how the brain can balance the demands of remaining sensitive to local rarity while utilising more global longer-term predictability to modulate cortical responses. In the present study auditory evoked potentials to four presentations of the same sound sequence containing predictable structure on a local (milliseconds to seconds) and more global (many minutes) timescales were recorded. The results from 33 participants are used to demonstrate that predictions about both local (internal predictive models) and global (meta-models that define expected precisions associated with familiar internal model states) regularities are formed. The study exposes more local context-based modulations of the P1 but more global order-based modulations of the auditory evoked N2 components. The results are discussed in terms of theoretical links advocating that uncertainty at multiple timescales could lead to differential component modulations, and the importance of considering the broader learning context in auditory evoked potential studies.
同时在多个时间尺度上进行感知推断的概念引发了一个问题，即大脑如何平衡保持对局部稀有性的敏感性的需求，同时利用更全局的长期可预测性来调节皮质反应。在本研究中，记录了对相同声音序列的四次呈现的听觉诱发电位，该声音序列在局部（毫秒到秒）和更全局（许多分钟）时间尺度上具有可预测的结构。来自 33 名参与者的结果用于证明可以形成对局部（内部预测模型）和全局（定义与熟悉内部模型状态相关的预期精度的元模型）规则的预测。该研究揭示了 P1 中更多基于局部上下文的调制，以及听觉诱发电位 N2 成分中更多基于全局顺序的调制。结果从多个时间尺度的不确定性可能导致不同成分调制的理论联系的角度进行了讨论，以及在听觉诱发电位研究中考虑更广泛的学习背景的重要性。
