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2000-2018 年澳大利亚与大麻相关的死亡人数、特征和方式。

Rates, characteristics and manner of cannabis-related deaths in Australia 2000-2018.

机构信息

National Drug & Alcohol Research Centre, University of New South Wales, NSW 2052, Australia.

National Drug & Alcohol Research Centre, University of New South Wales, NSW 2052, Australia.

出版信息

Drug Alcohol Depend. 2020 Jul 1;212:108028. doi: 10.1016/j.drugalcdep.2020.108028. Epub 2020 Apr 25.

Abstract

BACKGROUND

The most commonly used illicit substance worldwide is cannabis. To date, no national level study of cannabis-related death has been undertaken in Australia. The current study aimed to investigate the rates, characteristics and manner of cannabis-related deaths recorded in Australia (2000-2018).

METHODS

A retrospective case review of medicolegal files was undertaken through the National Coronial Information System (NCIS) (1/07/2000-31/12/2018).

RESULTS

A total of 559 cases were identified, with a mean age of 35.8 years, 81.2% were male. The crude mortality rate per 100,000 people ranged between 0.10 (CI = 0.06-0.15) and 0.23 (CI = 0.17-0.30). The manner of deaths were: accidental injury (29.9%), suicide (25.0%), polysubstance toxicity (17.0%), natural disease (16.1 %), natural disease and drug effect/toxicity (7.9%), assault (3.0%) and unascertained (1.1%). No deaths were solely due to cannabis toxicity. Men were over-represented in this group and were three times as likely to die of accidental injury than women who died from cannabis-related deaths. Motor vehicle accidents were the leading cause of accidental injury. Cardiovascular (14.3%) and respiratory conditions (9.7%) were the most common disease types recorded in cause of death. The median Δ-9-tetrahydrocannabinol blood concentration was 0.008 mg/L (range 0.0005-19.00 mg/L). Other drugs were cited in the cause of death alongside cannabis (81.4%), the most common being alcohol (47.2%).

CONCLUSIONS

Low all-cause crude mortality rates remained relatively stable over the study period. No deaths were due to direct cannabis toxicity, but death due to accidental injury was prominent.

摘要

背景

全球范围内最常使用的非法物质是大麻。迄今为止,澳大利亚尚未进行过全国范围内的与大麻相关死亡研究。本研究旨在调查澳大利亚(2000-2018 年)记录的与大麻相关死亡的发生率、特征和方式。

方法

通过国家法医信息系统(NCIS)(2000 年 7 月 1 日至 2018 年 12 月 31 日)对法医记录进行回顾性病例审查。

结果

共确定了 559 例病例,平均年龄为 35.8 岁,81.2%为男性。每 100,000 人中有 0.10(CI=0.06-0.15)至 0.23(CI=0.17-0.30)的粗死亡率。死亡方式为:意外伤害(29.9%)、自杀(25.0%)、多种物质毒性(17.0%)、自然疾病(16.1%)、自然疾病和药物效应/毒性(7.9%)、袭击(3.0%)和未确定(1.1%)。没有因大麻毒性而导致的死亡。男性在该组中占比过高,死于意外伤害的可能性是死于与大麻相关死亡的女性的三倍。机动车事故是意外伤害的主要原因。心血管疾病(14.3%)和呼吸系统疾病(9.7%)是记录的死亡原因中最常见的疾病类型。血液中 Δ-9-四氢大麻酚的中位数浓度为 0.008mg/L(范围 0.0005-19.00mg/L)。除大麻外,还有其他药物被列为死亡原因(81.4%),最常见的是酒精(47.2%)。

结论

在研究期间,全因粗死亡率保持相对稳定。没有直接因大麻毒性而导致的死亡,但意外伤害导致的死亡较为突出。

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