Cantone M C, Molho N, Pirola L, Gambarini G, Hansen C, Roth P, Werner E
Dipartimento di Fisica dell Universitá di Milano, Italy.
Med Phys. 1988 Nov-Dec;15(6):862-6. doi: 10.1118/1.596168.
An investigation of iron metabolism in a female patient volunteer by administration of stable iron isotopes as tracers was performed. The applied methodology had already been tested in rabbits in comparison with radioactive tracer technique. The subject under study was given 58Fe solution intravenously and about 45 min later 57Fe solution orally. Ten blood samples were drawn at different times within 522 min from injection. Single iron isotopes content in plasma samples was determined by proton nuclear activation. A Compton suppressor system was utilized to improve the detector limits. The characteristic parameters of iron plasma clearance and of iron intestinal absorption were determined.
通过给予稳定铁同位素作为示踪剂，对一名女性患者志愿者的铁代谢进行了研究。与放射性示踪技术相比，所应用的方法已经在兔子身上进行了测试。对研究对象静脉注射58Fe溶液，约45分钟后口服57Fe溶液。在注射后的522分钟内，于不同时间采集了10份血样。通过质子核活化测定血浆样本中的单一铁同位素含量。利用康普顿抑制系统提高探测器的检测限。测定了铁的血浆清除率和肠道吸收率等特征参数。
