Cantone M C, Molho N, Pirola L, Hansen C, Roth P, Werner E
Med Phys. 1987 Mar-Apr;14(2):223-7. doi: 10.1118/1.596136.
A methodology for ferrokinetic studies based on the administration of iron stable isotopes was developed. Fractional plasma clearance and intestinal iron absorption in rabbits were determined using the double tracer technique. Three rabbits were given 58Fe solution intravenously and about 40 min later 57Fe solution orally. Blood samples were drawn at different times following administration. The analysis of the single iron isotopes content in plasma samples was made by proton nuclear activation. The results were compared with those obtained from the administration, to the same rabbits, of the radioactive isotopes 55Fe and 59Fe. The agreement was found to be satisfactory.
开发了一种基于给予铁稳定同位素的铁动力学研究方法。采用双示踪技术测定了家兔的血浆清除率分数和肠道铁吸收。给3只家兔静脉注射58Fe溶液，约40分钟后口服57Fe溶液。给药后在不同时间采集血样。通过质子核活化分析血浆样品中单一铁同位素的含量。将结果与给同一家兔注射放射性同位素55Fe和59Fe所获得的结果进行比较。发现一致性令人满意。
