Saarland University Hospital, Department for Gynecology, Obstetrics and Reproductive Medicine, Kirrberger Straße 100, Building 9, 66421, Homburg, Germany.
University Hospital Leipzig, Department for Gynecology, Liebigstraße 20a, Building 6, 04103, Leipzig, Germany.
Sci Rep. 2020 May 5;10(1):7555. doi: 10.1038/s41598-020-64578-0.
The frequency and significance of sterility is increasing due to different socio-demographic factors in the industrialized countries. At the same time, the patients' demand for more natural and less invasive fertility treatments is increasing. The most common method used in subfertility is intrauterine insemination (IUI). Retrospectively, the data from the patients were analyzed, in which at least one insemination and a maximum of eight inseminations were performed in the last five years (observation period 01.01.2014-31.12.2018) at the Women's University Hospital Homburg. The primary endpoint was the onset of a clinical pregnancy. Clinical pregnancy was correlated with the partner's total sperm count (sperm density in millions), sperm concentration and motility during insemination. These three parameters were evaluated according the World Health Organization (WHO) 2010 guidelines. The results of the spermiograms were correlated with clinical pregnancy outcome. The data were examined for 138 women with sterility, in which a total of 345 inseminations were performed (median 2.5 per woman, range 8 inseminations). There was no correlation found between spermiogram parameters and pregnancy probability in any of the inseminations. After 5 inseminations no further pregnancy occurred. The present study showed no correlation between the conception probability of intrauterine insemination (IUI) and the total sperm count/concentration/motility. After the sixth IUI, we no longer found conceptions in our patient collective. Therefore, data from this study indicate that intrauterine inseminations can be performed at all severity levels of oligoasthenozoospermia. However, the treatment should be limited to five attempts.
由于工业化国家不同的社会人口因素，不育症的频率和重要性正在增加。与此同时，患者对更自然、侵入性更小的生育治疗的需求也在增加。在不育症中最常用的方法是宫腔内人工授精（IUI）。回顾性分析了过去五年（观察期为 2014 年 1 月 1 日至 2018 年 12 月 31 日）在妇女大学医院洪堡接受至少一次和最多八次授精的患者数据。主要终点是临床妊娠的发生。临床妊娠与配偶的总精子数（百万精子密度）、授精时的精子浓度和活力相关。这三个参数根据世界卫生组织（WHO）2010 年的指南进行评估。精液分析的结果与临床妊娠结局相关。对 138 名不育妇女的数据进行了检查，其中共进行了 345 次授精（中位数为每名妇女 2.5 次，范围为 8 次）。在任何一次授精中，精液分析参数与妊娠概率均无相关性。进行 5 次授精后不再发生妊娠。本研究表明，宫腔内人工授精（IUI）的受孕概率与总精子数/浓度/活力之间没有相关性。进行第六次 IUI 后，我们在患者群体中不再发现受孕。因此，本研究的数据表明，宫腔内人工授精可以在任何严重程度的少精症和弱精症中进行。然而，治疗应限制在五次尝试内。
