Hull M E, Magyar D M, Vasquez J M, Hayes M F, Moghissi K S
Am J Obstet Gynecol. 1986 Jun;154(6):1333-8. doi: 10.1016/0002-9378(86)90721-0.
In the past 100 years, interest in intrauterine insemination for cervical factor has waxed and waned. Recently the advent of in vitro fertilization, with improved methods of sperm washing and preparation, has revived interest in intrauterine insemination as a modality for the treatment of infertility. Twenty-seven couples with infertility resulting from cervical factor and/or oligospermia were entered into our intrauterine insemination protocol. A total of 107 intrauterine inseminations were performed in 85 menstrual cycles. Nineteen couples with a cervical factor as the major factor in their infertility experienced three pregnancies (16%). The remaining eight couples who had oligospermia with or without cervical factor produced no pregnancies. No major complications occurred from this procedure. In view of the low pregnancy rate experienced in this study, we must seriously question the value of intrauterine insemination in the treatment of cervical factors and/or oligospermia.
在过去的100年里，对于因宫颈因素进行宫腔内人工授精的兴趣一直起伏不定。最近，随着体外受精技术的出现，以及精子洗涤和制备方法的改进，人们对宫腔内人工授精作为治疗不孕症的一种方式又重新产生了兴趣。27对因宫颈因素和/或少精子症导致不孕的夫妇进入了我们的宫腔内人工授精方案。在85个月经周期中共进行了107次宫腔内人工授精。19对以宫颈因素为不孕主要因素的夫妇有3例妊娠（16%）。其余8对有或无宫颈因素的少精子症夫妇未出现妊娠。该操作未发生重大并发症。鉴于本研究中观察到的低妊娠率，我们必须认真质疑宫腔内人工授精在治疗宫颈因素和/或少精子症方面的价值。
