• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

PräVAC 试验的最终结果：采用表皮负压辅助伤口闭合技术预防阴茎癌患者腹股沟淋巴结清扫术后的伤口并发症。

Final results of the PräVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure.

机构信息

Department of Urology, Rechts der Isar Medical Center, Technical University of Munich, Ismaningerstr. 22, 81375, Munich, Germany.

Department of Urology, Universitätsklinikum Würzburg, Würzburg, Germany.

出版信息

World J Urol. 2021 Feb;39(2):613-620. doi: 10.1007/s00345-020-03221-z. Epub 2020 May 5.

DOI:10.1007/s00345-020-03221-z
PMID:32372159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7910363/
Abstract

PURPOSE

Inguinal lymphadenectomy in penile cancer is associated with a high rate of wound complications. The aim of this trial was to prospectively analyze the effect of an epidermal vacuum wound dressing on lymphorrhea, complications and reintervention in patients with inguinal lymphadenectomy for penile cancer.

PATIENTS AND METHODS

Prospective, multicenter, randomized, investigator-initiated study in two German university hospitals (2013-2017). Thirty-one patients with penile cancer and indication for bilateral inguinal lymph node dissection were included and randomized to conventional wound care on one side (CONV) versus epidermal vacuum wound dressing (VAC) on the other side.

RESULTS

A smaller cumulative drainage fluid volume until day 14 (CDF) compared to contralateral side was observed in 15 patients (CONV) vs. 16 patients (VAC), with a median CDF 230 ml (CONV) vs. 415 ml (VAC) and a median maximum daily fluid volume (MDFV) of 80 ml (CONV) vs. 110 ml (VAC). Median time of indwelling drainage: 7 days (CONV) vs. 8 days (VAC). All grade surgery-related complications were seen in 74% patients (CONV) vs. 74% patients (VAC); grade 3 complications in 3 patients (CONV) vs. 6 patients (VAC). Prolonged hospital stay occurred in 32% patients (CONV) vs. 48% patients (VAC); median hospital stay was 11.5 days. Reintervention due to complications occurred in 45% patients (CONV) vs. 42% patients (VAC).

CONCLUSIONS

In this prospective, randomized trial we could not observe a significant difference between epidermal vacuum treatment and conventional wound care.

摘要

目的

阴茎癌的腹股沟淋巴结清扫术会导致很高的伤口并发症发生率。本试验旨在前瞻性分析表皮负压伤口敷贴对阴茎癌腹股沟淋巴结清扫术患者淋巴液漏、并发症和再次干预的影响。

患者和方法

这是一项在两家德国大学医院进行的前瞻性、多中心、随机、研究者发起的研究（2013-2017 年）。纳入 31 例有阴茎癌且需要双侧腹股沟淋巴结清扫术的患者，并随机分为一侧采用常规伤口护理（CONV），另一侧采用表皮负压伤口敷贴（VAC）。

结果

15 例患者（CONV）与 16 例患者（VAC）相比，在第 14 天前的累积引流液量（CDF）较小，中位数 CDF 为 230ml（CONV）比 415ml（VAC），中位数最大日流量（MDFV）为 80ml（CONV）比 110ml（VAC）。留置引流时间中位数：7 天（CONV）比 8 天（VAC）。74%的患者（CONV）和 74%的患者（VAC）发生了所有分级手术相关并发症；3 例患者（CONV）和 6 例患者（VAC）发生了 3 级并发症。32%的患者（CONV）和 48%的患者（VAC）需要延长住院时间；中位住院时间为 11.5 天。由于并发症而需要再次干预的患者比例为 45%（CONV）和 42%（VAC）。

结论

在这项前瞻性、随机试验中，我们未观察到表皮负压治疗与常规伤口护理之间存在显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/74d1bad1c554/345_2020_3221_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/4af5fb837764/345_2020_3221_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/f9fb9d45b3ff/345_2020_3221_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/33efff91d28a/345_2020_3221_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/74d1bad1c554/345_2020_3221_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/4af5fb837764/345_2020_3221_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/f9fb9d45b3ff/345_2020_3221_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/33efff91d28a/345_2020_3221_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/483f/7910363/74d1bad1c554/345_2020_3221_Fig4_HTML.jpg

相似文献

1
Final results of the PräVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure.PräVAC 试验的最终结果：采用表皮负压辅助伤口闭合技术预防阴茎癌患者腹股沟淋巴结清扫术后的伤口并发症。
World J Urol. 2021 Feb;39(2):613-620. doi: 10.1007/s00345-020-03221-z. Epub 2020 May 5.
2
Inguinal lymph node dissection: epidermal vacuum therapy for prevention of wound complications.腹股沟淋巴结清扫术：表皮真空疗法预防伤口并发症。
J Plast Reconstr Aesthet Surg. 2013 Mar;66(3):390-6. doi: 10.1016/j.bjps.2012.09.030. Epub 2012 Oct 26.
3
Vacuum-assisted closure versus conventional wound care in the treatment of wound failures following inguinal lymphadenectomy for penile cancer: a retrospective study.阴茎癌腹股沟淋巴结清扫术后伤口愈合不良的治疗中，负压封闭引流与传统伤口护理的比较：一项回顾性研究。
Eur Urol. 2007 May;51(5):1320-5. doi: 10.1016/j.eururo.2006.12.027. Epub 2006 Dec 22.
4
[Inguinal lymphadenectomy in penile cancer: Study for prevention of wound complications after inguinal lymphadenectomy in patients with penile cancer by epidermal vacuum therapy (PräVAC, EUDAMED: CIV-12-07-008204; DRKS-ID: DRKS00005257)].阴茎癌腹股沟淋巴结清扫术：通过表皮真空疗法预防阴茎癌患者腹股沟淋巴结清扫术后伤口并发症的研究（PräVAC，欧盟医疗器械数据库：CIV-12-07-008204；德国临床试验注册中心编号：DRKS00005257）
Urologe A. 2015 Dec;54(12):1799-801. doi: 10.1007/s00120-015-4018-6.
5
[The use of negative pressure wound therapy to treat wound necrosis and groin lymphorrhea after inguinal lymph nodes dissection: a case report].[负压伤口治疗用于腹股沟淋巴结清扫术后伤口坏死及腹股沟淋巴漏的治疗：1例病例报告]
Nihon Hinyokika Gakkai Zasshi. 2012 Jan;103(1):22-6. doi: 10.5980/jpnjurol.103.22.
6
Radical open inguinal lymphadenectomy for penile carcinoma: surgical technique, early complications and late outcomes.根治性腹股沟淋巴结清扫术治疗阴茎癌：手术技术、早期并发症和晚期结果。
J Urol. 2013 Dec;190(6):2086-92. doi: 10.1016/j.juro.2013.06.016. Epub 2013 Jun 11.
7
Contemporary inguinal lymph node dissection: minimizing complications.当代腹股沟淋巴结清扫术：减少并发症
World J Urol. 2009 Apr;27(2):205-12. doi: 10.1007/s00345-008-0324-6. Epub 2008 Sep 2.
8
Use of incisional vacuum-assisted closure in the prevention of postoperative infection in high-risk patients who underwent spine surgery: a proof-of-concept study.切口负压封闭引流在脊柱手术后高危患者预防术后感染中的应用：一项概念验证研究。
J Neurosurg Spine. 2019 May 10;31(3):430-439. doi: 10.3171/2019.2.SPINE18947. Print 2019 Sep 1.
9
[Inguinal lymphadenectomy for penile cancer: study on the prevention of wound healing complications].阴茎癌腹股沟淋巴结清扫术：伤口愈合并发症预防研究
Urologe A. 2014 Apr;53(4):561-2. doi: 10.1007/s00120-014-3432-5.
10
Salvage surgical resection for isolated locally recurrent inguinal lymph node metastasis of penile cancer: international study collaboration.挽救性手术切除治疗阴茎癌孤立性局部复发性腹股沟淋巴结转移：国际研究协作。
J Urol. 2014 Sep;192(3):760-4. doi: 10.1016/j.juro.2014.02.2563. Epub 2014 Mar 3.

引用本文的文献

1
Penile cancer: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.阴茎癌：ESMO-EURACAN诊断、治疗及随访临床实践指南
ESMO Open. 2024 Jul;9(7):103481. doi: 10.1016/j.esmoop.2024.103481. Epub 2024 Jul 11.
2
Negative pressure wound therapy for surgical wounds healing by primary closure.负压伤口疗法在一期缝合手术伤口愈合中的应用。
Cochrane Database Syst Rev. 2022 Apr 26;4(4):CD009261. doi: 10.1002/14651858.CD009261.pub7.
3
Negative pressure wound therapy for surgical wounds healing by primary closure.

本文引用的文献

1
Adherence to the EAU guideline recommendations for systemic chemotherapy in penile cancer: results of the E-PROPS study group survey.遵循 EAU 指南推荐的阴茎癌全身化疗：E-PROPS 研究组调查结果。
World J Urol. 2020 Oct;38(10):2523-2530. doi: 10.1007/s00345-019-03052-7. Epub 2019 Dec 13.
2
Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival.阴茎癌的保器官手术：局部复发率较高，但对总体生存率无影响。
World J Urol. 2020 Feb;38(2):417-424. doi: 10.1007/s00345-019-02793-9. Epub 2019 May 6.
3
Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study.
负压伤口治疗用于通过一期缝合愈合的手术伤口。
Cochrane Database Syst Rev. 2020 Jun 15;6(6):CD009261. doi: 10.1002/14651858.CD009261.pub6.
4
Negative pressure wound therapy for surgical wounds healing by primary closure.负压伤口治疗用于通过一期缝合愈合的手术伤口。
Cochrane Database Syst Rev. 2020 May 1;5(5):CD009261. doi: 10.1002/14651858.CD009261.pub5.
遵循 EAU 阴茎癌指南可改善治疗结局：一项多中心国际研究。
World J Urol. 2019 Aug;37(8):1649-1657. doi: 10.1007/s00345-018-2549-3. Epub 2018 Oct 30.
4
A randomized clinical trial evaluating negative pressure therapy to decrease vascular groin incision complications.一项评估负压疗法以减少腹股沟血管切口并发症的随机临床试验。
J Vasc Surg. 2018 Dec;68(6):1744-1752. doi: 10.1016/j.jvs.2018.05.224. Epub 2018 Aug 17.
5
Closed Incision Negative Pressure Therapy Reduces Surgical Site Infections in Vascular Surgery: A Prospective Randomised Trial (AIMS Trial).闭合切口负压治疗减少血管外科手术部位感染：一项前瞻性随机试验（AIMS 试验）。
Eur J Vasc Endovasc Surg. 2018 Sep;56(3):442-448. doi: 10.1016/j.ejvs.2018.05.018. Epub 2018 Jun 30.
6
Closed-incision negative pressure therapy to reduce groin wound infections in vascular surgery: a randomised controlled trial.闭切口负压治疗减少血管外科腹股沟伤口感染：一项随机对照试验。
Int Wound J. 2018 Jun;15(3):327-332. doi: 10.1111/iwj.12848. Epub 2018 Mar 12.
7
A systematic review and meta-analysis including GRADE qualification of the risk of surgical site infections after prophylactic negative pressure wound therapy compared with conventional dressings in clean and contaminated surgery.一项系统评价和荟萃分析，包括对清洁-污染手术中预防性负压伤口治疗与传统敷料相比手术部位感染风险的GRADE分级。
Medicine (Baltimore). 2016 Sep;95(36):e4673. doi: 10.1097/MD.0000000000004673.
8
Radiocolloid-based dynamic sentinel lymph node biopsy in penile cancer with clinically negative inguinal lymph node: an updated systematic review and meta-analysis.基于放射性胶体的动态前哨淋巴结活检在腹股沟淋巴结临床阴性的阴茎癌中的应用：一项更新的系统评价和荟萃分析。
Int Urol Nephrol. 2016 Dec;48(12):2001-2013. doi: 10.1007/s11255-016-1405-x. Epub 2016 Aug 30.
9
Feasibility of performing dynamic sentinel lymph node biopsy as a delayed procedure in penile cancer.阴茎癌患者延迟进行动态前哨淋巴结活检的可行性。
World J Urol. 2016 Mar;34(3):329-35. doi: 10.1007/s00345-015-1577-5. Epub 2015 Jun 10.
10
EAU guidelines on penile cancer: 2014 update.EAU 指南：阴茎癌 2014 年更新版
Eur Urol. 2015 Jan;67(1):142-150. doi: 10.1016/j.eururo.2014.10.017. Epub 2014 Nov 1.