Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Sattarkhan-11 Niayesh St., Tehran, 14455-364, Iran.
Int Ophthalmol. 2020 Sep;40(9):2179-2183. doi: 10.1007/s10792-020-01398-1. Epub 2020 May 5.
To analyze and compare corneal endothelial mosaic in terms of endothelial cell population, morphology and irregularity in patients with xeroderma pigmentosum (XP) with clear corneas with normal age and sex matched subjects using specular microscopy.
Nine patients with XP without corneal involvement were evaluated in the study. An age and sex matched group of nine healthy subjects participated as control group. Evaluation of corneal endothelial layer was performed using specular microscopy.
Each study group consisted of five males and four females with total mean age of 28 ± 11.3 years (12-46 years). Endothelial cell density was significantly lower in patients with XP in comparison with controls (P < 0.002). Maximum and minimum cell areas were significantly higher in XP group (P < 0.016 and P < 0.029, respectively). Although central corneal thickness was higher in controls, the difference was not statistically significant (P = 0.106). Furthermore, our study showed that the patients with XP had no difference with controls in terms of coefficient of variation of cell areas.
This study showed that endothelial cell population can decrease in patients with XP, although other specular microscopic variables such as coefficient of variation and central corneal thickness may remain within normal values.
通过共焦显微镜分析和比较 XP 患者（无角膜受累）与年龄和性别相匹配的正常对照组的角膜内皮细胞群体、形态和不规则性。
本研究评估了 9 名 XP 无角膜受累的患者。9 名年龄和性别相匹配的健康受试者作为对照组参与研究。使用共焦显微镜评估角膜内皮层。
每组研究均包括 5 名男性和 4 名女性，总平均年龄为 28 ± 11.3 岁（12-46 岁）。与对照组相比，XP 患者的内皮细胞密度显著降低（P < 0.002）。XP 组的最大和最小细胞面积显著较高（P < 0.016 和 P < 0.029，分别）。尽管对照组的中央角膜厚度较高，但差异无统计学意义（P = 0.106）。此外，我们的研究表明，XP 患者的细胞面积变异系数与对照组无差异。
本研究表明，XP 患者的内皮细胞群体可能减少，尽管其他共焦显微镜变量，如变异系数和中央角膜厚度，可能仍在正常值范围内。
