Department of Ophthalmology, Bursa İznik State Hospital, İznik, Bursa, Turkey.
Department of Ophthalmology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.
Int Ophthalmol. 2022 Apr;42(4):1339-1345. doi: 10.1007/s10792-021-02122-3. Epub 2021 Nov 25.
To determine the structure and morphology of corneal endothelial cell layer in patients with acute anterior uveitis.
Thirty-four eyes of 34 acute anterior uveitis patients and 34 eyes of 34 healthy subjects were included. Mean cell density, coefficient of variation, maximum cell area, minimum cell area, average cell area and hexagonality ratio values were evaluated by non-contact specular microscopy. Parameters recorded in both groups were compared.
The mean maximum cell area was 1054,44 ± 251,14 µm, minimum cell area was 152.29 ± 53.65 µm and average cell area was 386.91 ± 41.73 µm in acute anterior uveitis group and the mean maximum cell area was 1057.65 ± 261.23 µm, minimum cell area was 147.26 ± 20.45 µm and average cell area was 383.53 ± 43.12 µm in the control group. There were no significant differences between the two groups in terms of maximum, minimum and average cell area (respectively, p = 0.080, p = 0.72, p = 0.62, p = 0.67). The mean cell density was 2607.74 ± 277.63 cells/ µm in acute anterior uveitis group and 2669.35 ± 265.22 cells/µm in the control group. (p = 0.358). In acute anterior uveitis group the mean coefficient of variation was 31.68 ± 8.16, hexagonality ratio was 63.85 ± 11.14 and mean central corneal thickness was 571.47 ± 55.99 µm; in control group the mean coefficient of variation was 25.29 ± 3.00, mean hexagonality ratio was 72.6 ± 4.80% and mean central corneal thickness was 534.82 ± 33.84 µm. Statistically significant differences were seen between the two groups (respectively, P = 0,00, P = 0,00, P = 0.02).
The mean central corneal thickness and coefficient of variation values were found higher, and the hexagonality ratio was found lower in acute anterior uveitis group. Our findings suggest that intraocular inflammation in anterior chamber negatively affects the endothelial function in patients with acute anterior uveitis.
确定急性前葡萄膜炎患者角膜内皮细胞层的结构和形态。
纳入 34 例急性前葡萄膜炎患者的 34 只眼和 34 例健康受试者的 34 只眼。采用非接触式共焦显微镜评估平均细胞密度、变异系数、最大细胞面积、最小细胞面积、平均细胞面积和六边形比值。比较两组记录的参数。
急性前葡萄膜炎组的最大平均细胞面积为 1054.44±251.14 µm，最小细胞面积为 152.29±53.65 µm，平均细胞面积为 386.91±41.73 µm；对照组的最大平均细胞面积为 1057.65±261.23 µm，最小细胞面积为 147.26±20.45 µm，平均细胞面积为 383.53±43.12 µm。两组间最大、最小和平均细胞面积无显著性差异（分别为 P=0.080、P=0.72、P=0.62、P=0.67）。急性前葡萄膜炎组的平均细胞密度为 2607.74±277.63 个/µm，对照组为 2669.35±265.22 个/µm（P=0.358）。在急性前葡萄膜炎组中，平均变异系数为 31.68±8.16%，六边形比值为 63.85±11.14%，中央角膜厚度为 571.47±55.99 µm；对照组的平均变异系数为 25.29±3.00%，平均六边形比值为 72.6±4.80%，中央角膜厚度为 534.82±33.84 µm。两组间差异有统计学意义（分别为 P=0.00、P=0.00、P=0.02）。
前房内眼内炎症使急性前葡萄膜炎患者的中央角膜厚度和变异系数值升高，六边形比值降低。我们的研究结果表明，前房内炎症会对急性前葡萄膜炎患者的内皮功能产生负面影响。
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