双相障碍患者和对照者之间的端粒长度差异受锂治疗的影响。
Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment.
机构信息
Department of Biomedical Science, Section of Neuroscience & Clinical Pharmacology, University of Cagliari, Monserrato, Cagliari, 09042, Italy.
Unit of Psychiatry, Department of Public Health, Clinical & Molecular Medicine, University of Cagliari, Cagliari, 09100, Italy.
出版信息
Pharmacogenomics. 2020 Jun;21(8):533-540. doi: 10.2217/pgs-2020-0028. Epub 2020 May 6.
To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.
评估锂治疗在双相情感障碍（BD）和白细胞端粒长度（LTL）之间的关系中的作用。我们比较了 131 名有或没有锂治疗史的 BD 患者和 336 名对照者之间的 LTL。我们在两个大型全基因组关联数据集测试了遗传决定的 LTL 与 BD 之间的关联。有锂治疗史的 BD 患者的 LTL 比从未治疗过的患者长（p=0.015），且与对照组相似。从未接受锂治疗的患者的 LTL 比对照组短（p=0.029）。孟德尔随机分析显示 BD 与遗传决定的 LTL 之间没有关联。我们的数据支持先前的研究结果，表明长期锂治疗可能有助于防止端粒缩短。
Zotero 插件