Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Psychiatry Res. 2018 Dec;270:41-49. doi: 10.1016/j.psychres.2018.09.035. Epub 2018 Sep 17.
The purpose of the present meta-analysis was to compare leukocyte telomere length (LTL), a proposed marker for cell aging, between patients with bipolar disorder (BD) and healthy controls and explore potential moderators for the LTL difference. We searched for the major research databases up to May 2018 for studies that examined LTL in patients with BD and healthy controls. The effect sizes (ESs) of LTL differences from the included studies were pooled using a random-effects model. Furthermore, we adopted subgroup analysis to investigate whether mood status of BD patients or methods for measuring telomere length may influence such differences. We included 10 studies, with a total of 579 patients and 551 controls, in the current meta-analysis and observed significantly shorter LTL in BD patients compared to control subjects. Such differences were found in studies with patients in all mood statuses and in studies using different methods for measuring telomere length. Late-stage BD patients demonstrated more significant LTL shortening than early-stage BD patients. Our current results support the hypothesis of accelerated aging in BD patients. In the future, further properly controlled longitudinal studies are warranted to determine whether LTL changes with disease status or medication use in BD patients.
本荟萃分析的目的是比较双相情感障碍（BD）患者和健康对照之间的白细胞端粒长度（LTL），这是一种细胞衰老的候选标志物，并探讨 LTL 差异的潜在调节因素。我们检索了主要的研究数据库，截至 2018 年 5 月，以寻找检查 BD 患者和健康对照者 LTL 的研究。使用随机效应模型汇总来自纳入研究的 LTL 差异的效应大小（ES）。此外，我们进行了亚组分析，以探讨 BD 患者的情绪状态或测量端粒长度的方法是否会影响这种差异。我们纳入了 10 项研究，共有 579 名患者和 551 名对照者，荟萃分析显示 BD 患者的 LTL 明显短于对照组。在所有情绪状态的患者研究和使用不同端粒长度测量方法的研究中均发现了这种差异。晚期 BD 患者的 LTL 缩短更为明显，而早期 BD 患者则不然。我们目前的结果支持 BD 患者加速衰老的假说。未来需要进一步进行适当控制的纵向研究，以确定 LTL 是否随 BD 患者的疾病状态或药物使用而变化。
