Diniz Breno S, Seitz-Holland Johanna, Sehgal Raghav, Kasamoto Jessica, Higgins-Chen Albert T, Lenze Eric
UConn Center on Aging & Department of Psychiatry (BSD), School of Medicine, University of Connecticut Health Center, Farmington, CT.
Department of Psychiatry (JSH), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry (JSH), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Am J Geriatr Psychiatry. 2024 Jan;32(1):1-16. doi: 10.1016/j.jagp.2023.09.014. Epub 2023 Sep 23.
The geroscience hypothesis asserts that physiological aging is caused by a small number of biological pathways. Despite the explosion of geroscience research over the past couple of decades, the research on how serious mental illnesses (SMI) affects the biological aging processes is still in its infancy. In this review, we aim to provide a critical appraisal of the emerging literature focusing on how we measure biological aging systematically, and in the brain and how SMIs affect biological aging measures in older adults. We will also review recent developments in the field of cellular senescence and potential targets for interventions for SMIs in older adults, based on the geroscience hypothesis.
老年科学假说认为，生理衰老由少数生物途径引起。尽管在过去几十年里老年科学研究激增，但关于严重精神疾病（SMI）如何影响生物衰老过程的研究仍处于起步阶段。在本综述中，我们旨在对新兴文献进行批判性评估，重点关注我们如何系统地测量生物衰老，以及在大脑中如何测量，以及严重精神疾病如何影响老年人的生物衰老指标。我们还将基于老年科学假说，综述细胞衰老领域的最新进展以及老年人严重精神疾病的潜在干预靶点。
