Yun Miyong, Yi Young-Su
Department of Bioindustry and Bioresource Engineering, Sejong University, Seoul, Republic of Korea.
Department of Life Science, Kyonggi University, Suwon, Republic of Korea.
J Ginseng Res. 2020 May;44(3):373-385. doi: 10.1016/j.jgr.2019.12.006. Epub 2019 Dec 24.
Inflammation is an immune response that protects against pathogens and cellular stress. The hallmark of inflammatory responses is inflammasome activation in response to various stimuli. This subsequently activates downstream effectors, that is, inflammatory caspases such as caspase-1, 4, 5, 11, and 12. Extensive efforts have been made on developing effective and safe anti-inflammatory therapeutics, and ginseng has long been traditionally used as efficacious and safe herbal medicine in treating various inflammatory and inflammation-mediated diseases. Many studies have successfully shown that ginseng plays an anti-inflammatory role by inhibiting inflammasomes and inflammasome-activated inflammatory caspases. This review discusses the regulatory roles of ginseng on inflammatory caspases in inflammatory responses and also suggests new research areas on the anti-inflammatory function of ginseng, which provides a novel insight into the development of ginseng as an effective and safe anti-inflammatory herbal medicine.
炎症是一种免疫反应，可抵御病原体和细胞应激。炎症反应的标志是对各种刺激作出反应时炎性小体激活。这随后激活下游效应分子，即炎性半胱天冬酶，如半胱天冬酶-1、4、5、11和12。人们在开发有效且安全的抗炎疗法方面付出了巨大努力，而人参长期以来一直被传统地用作治疗各种炎症和炎症介导疾病的有效且安全的草药。许多研究已成功表明，人参通过抑制炎性小体和炎性小体激活的炎性半胱天冬酶发挥抗炎作用。本综述讨论了人参在炎症反应中对炎性半胱天冬酶的调节作用，并提出了关于人参抗炎功能的新研究领域，这为将人参开发成一种有效且安全的抗炎草药提供了新的见解。
