School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shenyang Pharmaceutical University, Shenyang 110016, China.
Food Funct. 2019 Jul 17;10(7):3992-4000. doi: 10.1039/c8fo02405g.
Ginseng is a type of medicinal and edible homologous plant that is very common in medicine, food and even cosmetics. Ginsenosides are the main active constituents of ginseng, which has many pharmacological activities. AD-2 is a type of ginsenoside extracted from ginseng and prepared in large quantities in our laboratory. However, the anti-fibrosis effects and mechanism of ginsenosides are rarely reported. In this study, the anti-fibrosis pharmacodynamics of AD-2 were evaluated. The results revealed that AD-2 could reduce the expression of collagen I, TIMP-1 and MMP-13, inhibit the deposition of extracellular matrix, and play an role in anti-hepatic fibrosis. The mechanism and related pathways of AD-2 against liver fibrosis have also been studied. Inflammatory factors (including TNF-α, IL-1β, caspase-1 and IL-6) associated with hepatic fibrosis, and the p-JNK and the p38-ERK pathways, have been shown to be associated with the anti-fibrotic effect of AD-2. In conclusion, our study reveals that AD-2, as a small-molecule, targeted drug for improving liver function, needs further study.
人参是一种药用和食用同源植物，在医学、食品甚至化妆品中都非常常见。人参皂苷是人参的主要活性成分，具有多种药理作用。AD-2 是从人参中提取并在我们实验室大量制备的一种人参皂苷。然而，人参皂苷的抗纤维化作用及其机制很少有报道。本研究评价了 AD-2 的抗纤维化药效学。结果表明，AD-2 可降低胶原 I、TIMP-1 和 MMP-13 的表达，抑制细胞外基质的沉积，发挥抗肝纤维化作用。还研究了 AD-2 抗肝纤维化的机制及相关途径。与肝纤维化相关的炎症因子（包括 TNF-α、IL-1β、caspase-1 和 IL-6）以及 p-JNK 和 p38-ERK 途径，均显示与 AD-2 的抗纤维化作用有关。总之，本研究表明 AD-2 作为一种改善肝功能的小分子靶向药物，需要进一步研究。
