Horváth Balázs, Hézső Tamás, Kiss Dénes, Kistamás Kornél, Magyar János, Nánási Péter P, Bányász Tamás
Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.
Front Pharmacol. 2020 Apr 20;11:413. doi: 10.3389/fphar.2020.00413. eCollection 2020.
Based on recent findings, an increased late sodium current (I) plays an important pathophysiological role in cardiac diseases, including rhythm disorders. The article first describes what is I and how it functions under physiological circumstances. Next, it shows the wide range of cellular mechanisms that can contribute to an increased I in heart diseases, and also discusses how the upregulated I can play a role in the generation of cardiac arrhythmias. The last part of the article is about I inhibiting drugs as potential antiarrhythmic agents, based on experimental and preclinical data as well as in the light of clinical trials.
基于最近的研究发现，晚钠电流（I）增加在包括心律失常在内的心脏疾病中发挥着重要的病理生理作用。本文首先描述了什么是晚钠电流（I）以及它在生理情况下如何发挥作用。接下来，阐述了在心脏疾病中可导致晚钠电流（I）增加的多种细胞机制，还讨论了上调的晚钠电流（I）如何在心律失常的发生中发挥作用。本文的最后一部分是基于实验和临床前数据以及临床试验，探讨晚钠电流（I）抑制药物作为潜在抗心律失常药物的情况。
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