Horvath Balazs, Bers Donald M
Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.
ESC Heart Fail. 2014 Sep;1(1):26-40. doi: 10.1002/ehf2.12003.
Large and growing body of data suggest that an increased late sodium current (I ) can have a significant pathophysiological role in heart failure and other heart diseases. The first goal of this article is to describe how I functions under physiological circumstances. The second goal is to show the wide range of cellular mechanisms that can increase I in cardiac disease, and also to describe how the up-regulated I contributes to the pathophysiology of heart failure. The final section of the article discusses the possible use of I -modifying drugs in heart failure, on the basis of experimental and preclinical data.
大量且不断增加的数据表明，晚钠电流（I）增加在心力衰竭和其他心脏病中可能具有重要的病理生理作用。本文的首要目标是描述I在生理情况下的功能。第二个目标是展示在心脏病中可增加I的广泛细胞机制，并描述上调的I如何促成心力衰竭的病理生理学。本文的最后一部分基于实验和临床前数据讨论了I修饰药物在心力衰竭中的可能用途。
