一种非典型抗心律失常药物对心脏钠通道阻滞的新见解。 - Suppr

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超能文献

New insights on cardiac Na channel block by an atypical anti-arrhythmic drug.

作者信息

Fossier Lucile, Ben-Johny Manu

机构信息

Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.

出版信息

Nat Cardiovasc Res. 2023 Jun;2(6):494-495. doi: 10.1038/s44161-023-00284-0.

DOI:10.1038/s44161-023-00284-0

PMID:39195887

Abstract

摘要

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Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current.成纤维细胞生长因子同源因子在调节致心律失常性心脏晚钠电流中起分子变阻器的作用。

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Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na 1.5 by the Antiarrhythmic Drug Quinidine*.抗心律失常药物奎尼丁*阻塞人心房钠通道 Na 1.5 的孔道结构基础。

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Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents.晚期钠电流抑制剂作为潜在的抗心律失常药物。

Front Pharmacol. 2020 Apr 20;11:413. doi: 10.3389/fphar.2020.00413. eCollection 2020.

Structure of the Cardiac Sodium Channel.心脏钠离子通道的结构。

Cell. 2020 Jan 9;180(1):122-134.e10. doi: 10.1016/j.cell.2019.11.041. Epub 2019 Dec 19.

Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model.艾莱卡嗪是一种新型选择性心脏晚期钠电流抑制剂，在完整猪模型中可同时预防自主神经诱导的房性早搏、复极交替和复极离散以及房颤。

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