Tan Shengnan, Hua Xin, Xue Zheyong, Ma Jianzhang
Key Laboratory of Saline-alkali Vegetation Ecology Restoration (Northeast Forestry University), Ministry of Education, Harbin, China.
College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Front Pharmacol. 2020 Apr 15;11:473. doi: 10.3389/fphar.2020.00473. eCollection 2020.
Antimicrobial resistance has become a serious threat to human and animal health, and vancomycin-resistant has become an important nosocomial infection pathogen, causing thousands of deaths each year. In this study, after screening a variety of natural products, we found that cajanin stilbene acid (CSA) had significant inhibitory effect on sensitive and vancomycin-resistant (VRE) . And we also confirmed that CSA had significant anti-VRE infection ability . Subsequently, we studied the antibacterial mechanism of CSA through proteomics experiments, and the results showed that CSA killed by inhibiting the phosphotransferase system of , thus hinders the normal growth and metabolic functions of bacteria. The results of this study provided evidence for the in-depth study on the mechanism of the antibacterial action of CSA and also provided a candidate for the development of anti-VRE drugs.
抗菌耐药性已成为对人类和动物健康的严重威胁，耐万古霉素肠球菌已成为一种重要的医院感染病原体，每年导致数千人死亡。在本研究中，在筛选了多种天然产物后，我们发现木豆素二苯乙烯酸（CSA）对敏感和耐万古霉素肠球菌（VRE）具有显著的抑制作用。并且我们还证实CSA具有显著的抗VRE感染能力。随后，我们通过蛋白质组学实验研究了CSA的抗菌机制，结果表明CSA通过抑制肠球菌的磷酸转移酶系统杀死肠球菌，从而阻碍细菌的正常生长和代谢功能。本研究结果为深入研究CSA抗菌作用机制提供了依据，也为抗VRE药物的开发提供了一个候选物。
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