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细菌性感染的肠外初始治疗方案：骨与关节感染

Calculated parenteral initial treatment of bacterial infections: Bone and joint infections.

作者信息

Vossen Mathias G, Gattringer Rainer, Thalhammer Florian, Militz Matthias, Hischebeth Gunnar

机构信息

Medizinische Universität Wien, Universitätsklinik für Innere Medizin I, Klinische Abteilung für Infektionen & Tropenmedizin, Allgemeines Krankenhaus Wien, Vienna, Austria.

Institut für Hygiene und Mikrobiologie, Klinikum Wels Grieskirchen, Wels, Austria.

出版信息

GMS Infect Dis. 2020 Mar 26;8:Doc10. doi: 10.3205/id000054. eCollection 2020.

DOI:10.3205/id000054
PMID:32373435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7186792/
Abstract

This is the 10 chapter of the guideline "Calculated initial parenteral treatment of bacterial infections in adults - update 2018" in the 2 updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG) has been translated to address an international audience. This chapter deals with bacterial Infections of bones, joints and prosthetic joints. One of the most pressing points is that after an initial empirical therapy a targeted antimicrobial which penetrates well to the point of infection and is tolerated well over the usually long duration of the therapy is chosen.

摘要

这是《成人细菌性感染的初始肠外计算治疗指南 - 2018年更新》第2版更新中的第10章。保罗·埃尔利希化疗协会（PEG）的德国指南已被翻译，以面向国际受众。本章涉及骨骼、关节和人工关节的细菌感染。最紧迫的要点之一是，在初始经验性治疗后，要选择一种能很好地渗透到感染部位且在通常较长的治疗期间耐受性良好的靶向抗菌药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f1/7186792/cfefabaa91d1/ID-08-10-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f1/7186792/cfefabaa91d1/ID-08-10-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94f1/7186792/cfefabaa91d1/ID-08-10-t-001.jpg

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In vivo emergence of ceftaroline resistance during therapy for MRSA vertebral osteomyelitis.耐甲氧西林金黄色葡萄球菌（MRSA）性椎体骨髓炎治疗期间头孢洛林耐药性的体内出现
J Antimicrob Chemother. 2016 Jun;71(6):1736-8. doi: 10.1093/jac/dkw001. Epub 2016 Feb 9.
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Validation of a treatment algorithm for orthopaedic implant-related infections with device-retention-results from a prospective observational cohort study.验证一种针对骨科植入物相关感染的治疗算法，该算法保留了装置-研究结果来自一项前瞻性观察队列研究。
Clin Microbiol Infect. 2016 May;22(5):457.e1-9. doi: 10.1016/j.cmi.2016.01.004. Epub 2016 Jan 20.
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Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections.
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GMS Infect Dis. 2020 Mar 26;8:Doc20. doi: 10.3205/id000064. eCollection 2020.
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GMS Infect Dis. 2020 Mar 26;8:Doc14. doi: 10.3205/id000058. eCollection 2020.
夫西地酸：一种用于口服治疗急慢性葡萄球菌感染的细菌延伸因子抑制剂。
Cold Spring Harb Perspect Med. 2016 Jan 4;6(1):a025437. doi: 10.1101/cshperspect.a025437.
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Occult Infection in Aseptic Joint Loosening and the Diagnostic Role of Implant Sonication.无菌性关节松动中的隐匿性感染及植入物超声处理的诊断作用
Biomed Res Int. 2015;2015:946215. doi: 10.1155/2015/946215. Epub 2015 Oct 25.
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