Stahlmann Ralf, Lode Hartmut
Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, Germany.
Research Center Charlottenburg, Berlin, Germany.
GMS Infect Dis. 2020 Mar 26;8:Doc16. doi: 10.3205/id000060. eCollection 2020.
This is the fourth chapter of the guideline "Calculated initial parenteral treatment of bacterial infections in adults - update 2018" in the 2 updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG) has been translated to address an international audience. Safety and tolerability of antimicrobial agents will be discussed in this chapter. Toxic, allergic and biological effects can be differentiated on the basis of their pathogenesis. The question of differences in the tolerability of specific antibiotics is of particular importance. However, due to limitations of the available data, it cannot be answered for most agents with the desired accuracy. For an assessment of rare side effects, results from the postmarketing surveillance have to be used.
这是2018年更新的第2版“成人细菌性感染的初始肠外计算治疗指南”的第四章。保罗·埃尔利希化疗协会（PEG）的德国指南已被翻译，以面向国际受众。本章将讨论抗菌药物的安全性和耐受性。毒性、过敏和生物学效应可根据其发病机制进行区分。特定抗生素耐受性差异的问题尤为重要。然而，由于现有数据的局限性，对于大多数药物，无法以所需的准确性回答该问题。对于罕见副作用的评估，必须使用上市后监测的结果。
