Kurteva Elena, Bamford Alasdair, Cross Kate, Watson Tom, Owens Catherine, Cheng Fanlek, Hartley John, Harris Kathryn, Johnson Elizabeth M, Lindley Keith, Levine Samantha, Köglmeier Jutta
Great Ormond Street Hospital for Children, London, United Kingdom.
Front Pediatr. 2020 Apr 21;8:142. doi: 10.3389/fped.2020.00142. eCollection 2020.
Basidiobolomycosis is a rare fungal disease caused by . Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of . He made a full recovery with a combination of surgery and prolonged targeted antifungal medication.
担子菌病是一种由……引起的罕见真菌病。胃肠道受累情况不常见，并且带来诊断和治疗方面的挑战，因为临床症状不具特异性且缺乏易感风险因素。它可酷似炎症性肠病、原发性免疫缺陷或恶性肿瘤，对于对标准治疗无反应的患者应考虑此病。我们报告一例确诊为结肠担子菌病的22个月大男孩病例，该患儿出现严重的胃肠道嗜酸性粒细胞炎症。对直接从组织样本中提取的DNA进行的泛真菌聚合酶链反应（PCR）证实存在……。通过手术和长期针对性抗真菌药物联合治疗，他完全康复。
