Hubei Key Laboratory of Medical Technology on Transplantation, Transplant Center of Wuhan University, Institute of Hepatobiliary Disease of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
J Mater Chem B. 2020 Jun 7;8(21):4648-4659. doi: 10.1039/d0tb00735h. Epub 2020 May 6.
Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis. Herein, we present a platelet membrane-facilitated local chemo-photothermal therapy strategy, in which polypyrrole (PPy) nanoparticles act as photothermal agents and along with antitumor drug doxorubicin (DOX) are encapsulated into platelet membranes (PLT-PPy-DOX). The particles are endowed with immune evasiveness and tumor targeting abilities from platelet membranes, and are then intravenously injected into an orthotopic mouse model of HCC. As expected, the PLT-PPy-DOX nanoplatforms were abundant in the tumor tissues. Hyperthermia was generated under laser irradiation (808 nm) not only to ablate tumor cells directly but also to increase the triggered release of DOX. This combination of local chemotherapy and photothermal therapy demonstrated excellent antitumor efficiency in suppressing primary tumor growth and inhibiting tumor metastases. This localized therapy which adopts biocompatible natural cell membranes and good biodegradable organic photothermal agents may provide new insights into designing biomimetic nano-vehicles for personalized therapy of HCC.
在肝癌（HCC）治疗中，特别是在转移后，实现肿瘤区域的特定靶向药物输送和药物可控释放是两个主要挑战。在此，我们提出了一种血小板膜介导的局部化疗-光热治疗策略，其中聚吡咯（PPy）纳米颗粒作为光热剂，并与抗肿瘤药物阿霉素（DOX）一起封装在血小板膜（PLT-PPy-DOX）中。这些颗粒具有来自血小板膜的免疫逃逸和肿瘤靶向能力，然后静脉注射到 HCC 的原位小鼠模型中。正如预期的那样，PLT-PPy-DOX 纳米平台在肿瘤组织中丰富。在激光照射（808nm）下产生的热疗不仅可以直接消融肿瘤细胞，还可以增加 DOX 的触发释放。局部化疗和光热治疗的联合应用在抑制原发性肿瘤生长和抑制肿瘤转移方面表现出了优异的抗肿瘤效率。这种采用生物相容性天然细胞膜和良好的可生物降解有机光热剂的局部治疗方法可能为 HCC 的个性化治疗设计仿生纳米载体提供新的思路。
