Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
J Vet Pharmacol Ther. 2020 Jul;43(4):331-338. doi: 10.1111/jvp.12868. Epub 2020 May 6.
Ethanamizuril is a new triazine compound that shows potential for application in novel anticoccidial treatment. In this study, a pharmacokinetic model of ethanamizuril was established on the basis of the blood concentration of 81 experimental animals. The final model showed that ethanamizuril was distributed as a two-compartment model with first-order absorption after oral administration in chickens. Its clearance rate and volumn of central compartment distribution (V ) were affected by age and body weight, and volumn of central compartment distribution (V ) and volume of peripheral compartment distribution(V ) were influenced by weight and infection. External verification revealed that the model had good prediction accuracy and stability.
依拉美祖，一种新型三嗪化合物，显示出在新型抗球虫病治疗中的应用潜力。在这项研究中，基于 81 只实验动物的血液浓度，建立了依拉美祖的药代动力学模型。最终模型表明，依拉美祖在鸡体内口服吸收呈二室模型分布，为一级吸收。其清除率和中央室分布容积(V )受到年龄和体重的影响，中央室分布容积(V )和外周室分布容积(V )受到体重和感染的影响。外部验证表明，该模型具有良好的预测准确性和稳定性。
