Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
China College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou 510642, China.
Vet Parasitol. 2021 Jan;289:109318. doi: 10.1016/j.vetpar.2020.109318. Epub 2020 Nov 14.
The treatment effect of ethanamizuril (EZL) to broiler chickens experimentally infected with 8 × 10Eimeria tenella was evaluated. On the third day after infection, the broiler chickens were treated with EZL by gavage at doses of 2, 4, and 8 mg/kg body weight (bw) for once. For double administration, the challenged broiler chickens were administered EZL at doses of 1, 2, 4, and 8 mg/kg bw by gavage continually on the third day and fourth day and once a day. Throughout the experimental period, performance parameters including body weight gain, mortality, cecal lesion score, bloody diarrhoea and oocyst output were recorded. The anticoccidial efficacy was evaluated using the anticoccidial index (ACI). Meanwhile, the concentrations of EZL in chicken cecal contents were measured, and the data were analyzed with a non-compartmental model. The results indicated that EZL showed good anticoccidial activity at single dose of 4 mg/kgbw, with the corresponding ACI of 175.73. When the challenged chickens were treated with EZL under double administration, the EZL showed a medium level of anticoccidial activity at a dose of 2 mg/kg bw, with the corresponding ACI of 162.48. The maximum concentrations (C) of EZL in content were 2.43 ± 1.16, 4.28 ± 1.56, and 8.57 ± 1.33 mg/kg after the chickens were administrated at doses of 2, 4, and 8 mg/kg bw, respectively. The respective areas under the curve were 36.93 ± 8.91, 96 ± 16.31, and 262.76 ± 51.52 mg/kg h. The respective half-lives (T) were 10.82 ± 2.02, 10.53 ± 2.23, and 10.60 ± 1.50 h. The results show that when the concentrations of EZL in chicken cecal contents reached 4.28 ± 1.56 mg/kg, there is a significant therapeutic effect on chicken coccidiosis.
评价了二甲氧苄啶（EZL）对 8×10 柔嫩艾美耳球虫感染的肉鸡的治疗效果。感染后第 3 天，通过灌胃给予肉鸡 EZL，剂量分别为 2、4 和 8mg/kg 体重（BW），单次给药。对于双重给药，用 EZL 以 1、2、4 和 8mg/kg BW 的剂量连续在第 3 天和第 4 天灌胃，并每天一次对感染的肉鸡进行给药。在整个实验期间，记录体重增加、死亡率、盲肠病变评分、血性腹泻和卵囊排出等性能参数。使用抗球虫指数（ACI）评估抗球虫效果。同时，测量鸡盲肠内容物中 EZL 的浓度，并使用非房室模型分析数据。结果表明，EZL 在单剂量 4mg/kgBW 时表现出良好的抗球虫活性，相应的 ACI 为 175.73。当感染鸡接受双重给药时，EZL 在 2mg/kgBW 剂量下表现出中等水平的抗球虫活性，相应的 ACI 为 162.48。鸡分别以 2、4 和 8mg/kgBW 剂量给药后，EZL 在内容物中的最大浓度（C）分别为 2.43±1.16、4.28±1.56 和 8.57±1.33mg/kg。相应的 AUC 分别为 36.93±8.91、96±16.31 和 262.76±51.52mg/kg·h。相应的半衰期（T）分别为 10.82±2.02、10.53±2.23 和 10.60±1.50h。结果表明，当鸡盲肠内容物中 EZL 的浓度达到 4.28±1.56mg/kg 时，对鸡球虫病有显著的治疗效果。
