Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
College of Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Genes (Basel). 2020 May 4;11(5):505. doi: 10.3390/genes11050505.
Ancestry informative markers are genetic markers that show distinct genetic divergences among different populations. These markers can be utilized to discern population substructures and estimate the ancestral origins of unknown individuals. Previously, we developed a multiplex system of 30 ancestry informative single nucleotide polymorphism (AISNP) loci to facilitate ancestral inferences in different continental populations. In the current study, we first compared the ancestry resolutions of the 30 AISNPs and the other previously reported AISNP panels for African, European, East Asian, South Asian and American populations. Next, the genetic components of the Xinjiang Hui group were further explored in comparison to these continental populations based on the 30 AISNPs. Genetic divergence analyses of the 30 AISNPs in these five continental populations revealed that most of the AISNPs showed high genetic differentiations between these populations. Ancestry analysis comparisons of the 30 AISNPs and other published AISNPs revealed that these 30 AISNPs had comparable efficiency to other AISNP panels. Genetic relationship analyses among the studied Hui group and other continental populations demonstrated that the Hui group had close genetic affinities with East Asian populations and might share the genetic ancestries with East Asian populations. Overall, the 30 AISNPs can be used to predict the bio-geographical origins of different continental populations. Moreover, the obtained genetic data of 30 AISNPs in the Hui group can further enrich the extant reference data, which can be used as reference data for ancestry analyses of the Hui group.
祖先信息标记是显示不同人群之间明显遗传差异的遗传标记。这些标记可用于辨别人群亚结构，并估计未知个体的祖先起源。此前，我们开发了一个 30 个单核苷酸多态性（AISNP）的多重祖先信息标记系统，以方便在不同大陆人群中进行祖先推断。在本研究中，我们首先比较了 30 个 AISNP 与以前报道的非洲、欧洲、东亚、南亚和美洲人群中其他 AISNP 面板的祖先分辨率。接下来，根据 30 个 AISNP，与这些大陆人群相比，进一步探讨了新疆回族群体的遗传构成。对这五个大陆人群中的 30 个 AISNP 的遗传分化分析表明，大多数 AISNP 在这些人群之间表现出高度的遗传分化。30 个 AISNP 与其他已发表的 AISNP 的祖先分析比较表明，这些 30 个 AISNP 与其他 AISNP 面板具有相当的效率。研究的回族群体与其他大陆人群之间的遗传关系分析表明，回族群体与东亚人群具有密切的遗传亲缘关系，可能与东亚人群具有共同的遗传祖先。总的来说，30 个 AISNP 可用于预测不同大陆人群的生物地理起源。此外，回族群体中 30 个 AISNP 的获得的遗传数据可以进一步丰富现有的参考数据，可作为回族群体祖先分析的参考数据。
