Mori H, Maeda T, Saitoh Y, Onishi T
Department of Pathology, Osaka Medical College, Japan.
Pathol Res Pract. 1988 Sep;183(5):580-3. doi: 10.1016/S0344-0338(88)80015-3.
Effects of bromocriptine (CB) on human prolactin (PRL)-secreting adenomas (PRLomas) and growth hormone-secreting adenomas (GHomas) were analyzed morphologically and morphometrically. Treatment with CB for 2 weeks brought about a variety of changes in PRLomas, including cell shrinkage, degenerative and necrotic changes and fibrosis. Secretory granules within a cell increased in number but not in volume. However, the exocytosis of the granules increased remarkably. Single-cell necrosis was occasionally seen in the tumor nests, whereas breakdown of tumor cells occurred in clusters predominantly in the periphery of the nests. At 1 week after cessation of CB, PRLomas showed two distinct, divergent histological appearances; more advanced destructive changes and the regrowth. These findings suggest that human PRLomas consist of two populations, i.e., those sensitive and resistant to the cytocidal actions of CB. In contrast, treatment with CB produced almost no change in GHomas except for an increase in the stromal tissue volume. Vacuolation and single-cell necrosis were occasionally observed in a few GHomas.
分析了溴隐亭（CB）对人催乳素（PRL）分泌性腺瘤（PRL瘤）和生长激素分泌性腺瘤（GH瘤）的形态学和形态计量学影响。用CB治疗2周后，PRL瘤出现了多种变化，包括细胞萎缩、变性和坏死变化以及纤维化。细胞内的分泌颗粒数量增加但体积未变。然而，颗粒的胞吐作用显著增加。肿瘤巢中偶尔可见单细胞坏死，而肿瘤细胞的崩解主要发生在巢周边的簇状区域。在停止使用CB 1周后，PRL瘤呈现出两种截然不同、相互背离的组织学表现；更严重的破坏性变化和再生长。这些发现表明，人PRL瘤由两个群体组成，即对CB的杀细胞作用敏感和耐药的群体。相比之下，CB治疗除了基质组织体积增加外，对GH瘤几乎没有产生变化。少数GH瘤中偶尔观察到空泡化和单细胞坏死。
