情感性疾病患者锂药代动力学的研究。
Studies of lithium pharmacokinetics in patients with affective illness.
作者信息
Lehmann W, Kanarkowski R, Matkowski K, Rybakowski J
机构信息
Department of Psychiatry, Bydgoszcz Medical Academy, Poland.
出版信息
Pol J Pharmacol Pharm. 1988 Jan-Feb;40(1):47-54.
Lithium pharmacokinetics after a single dose and pharmacokinetic prediction of optimal lithium carbonate dose in steady-state, were investigated in 15 patients with affective illness. In nine patients the course of plasma concentration after a single dose was characteristic for two-compartment and in six patients for one-compartment model. Patients fitting the two-compartment model required higher daily lithium dose to achieve steady-state therapeutic lithium level than patients fitting the one-compartment model. A significant correlation was found between plasma lithium level 12 and 24 h after a single dose and the daily dose required for achieving optimal lithium level in the course of subsequent lithium administration.
对15例情感性疾病患者进行了单次给药后的锂药代动力学及稳态时碳酸锂最佳剂量的药代动力学预测研究。9例患者单次给药后的血药浓度过程符合二室模型特征，6例患者符合一室模型特征。与符合一室模型的患者相比，符合二室模型的患者达到稳态治疗锂水平所需的每日锂剂量更高。单次给药后12小时和24小时的血浆锂水平与后续锂给药过程中达到最佳锂水平所需的每日剂量之间存在显著相关性。
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