Marr M A, Djuric P E, Ritschel W A, Garver D L
Clin Pharm. 1983 May-Jun;2(3):243-8.
A repeated one-point pharmacokinetic model of predicting lithium carbonate doses was evaluated. Six psychiatric inpatients with normal renal function who required lithium therapy were given two 600-mg lithium carbonate test doses 12 hours apart. Serum lithium concentrations were determined 11 hours after each test dose. Based on these determinations, the patients were then given individualized lithium doses to reach a minimum steady-state serum concentration of 1.0 meq/liter. The measured and predicted minimum steady-state concentrations were compared. The mean +/- S.D. measured and predicted minimum steady-state serum concentrations for all patients were 1.03 +/- 0.06 meq/liter and 0.97 +/- 0.08 meq/liter, respectively. While further studies are needed to evaluate the method, the repeated one-point pharmacokinetic model provided accurate predictions of lithium carbonate doses in these patients.
对一种预测碳酸锂剂量的重复单点药代动力学模型进行了评估。六名肾功能正常且需要锂治疗的精神科住院患者，每隔12小时给予两次600毫克碳酸锂测试剂量。在每次测试剂量后11小时测定血清锂浓度。根据这些测定结果，随后给患者给予个体化锂剂量，以使最低稳态血清浓度达到1.0毫当量/升。比较了测量的和预测的最低稳态浓度。所有患者测量的和预测的最低稳态血清浓度的平均值±标准差分别为1.03±0.06毫当量/升和0.97±0.08毫当量/升。虽然需要进一步研究来评估该方法，但重复单点药代动力学模型在这些患者中对碳酸锂剂量提供了准确的预测。
