Fernández-Caso Belén, Fraile Arturo Manuel, Rodríguez Marta Soledad, Fernández Inmaculada, Buendía Buenaventura
Servicio de Microbiología, Hospital Universitario de La Princesa, Madrid, España; Instituto de Investigación Sanitaria La Princesa, Madrid, España.
Servicio de Microbiología, Hospital Universitario de La Princesa, Madrid, España; Instituto de Investigación Sanitaria La Princesa, Madrid, España.
Rev Iberoam Micol. 2020 Apr-Jun;37(2):65-67. doi: 10.1016/j.riam.2020.02.004. Epub 2020 May 4.
Schizophyllum commune is a basidiomycete fungus which is widely distributed in nature. Its role as responsible for disease in humans is not well known, partly due to its difficult identification. The incorporation of mass spectrometry techniques (MALDI-TOF) and molecular biology to the laboratories has allowed the description of a greater number of cases.
In this paper, we present two cases in which S. commune was identified as the causative agent of disease: in the first case an immunocompetent patient suffered from chronic rhinosinusitis, and in the second one a sphenoid sinus infection was diagnosed in an immunocompromised patient. In both cases, S. commune was isolated. Its identification was possible by means of MALDI-TOF and this was confirmed in both patients by amplification and sequencing of the ITS region.
In conclusion, S. commune should be considered a potential causative agent of fungal disease. Currently, MALDI-TOF and sequencing techniques are necessary for its identification.
裂褶菌是一种担子菌真菌，在自然界中广泛分布。其作为人类疾病病原体的作用尚不清楚，部分原因是其难以鉴定。质谱技术（基质辅助激光解吸电离飞行时间质谱，MALDI-TOF）和分子生物学技术引入实验室后，已有更多病例被报道。
本文介绍了两例裂褶菌被鉴定为疾病病原体的病例：第一例中，一名免疫功能正常的患者患有慢性鼻窦炎；第二例中，一名免疫功能低下的患者被诊断为蝶窦感染。在这两例中均分离出了裂褶菌。通过MALDI-TOF实现了其鉴定，并通过ITS区域的扩增和测序在两名患者中得到了证实。
总之，裂褶菌应被视为真菌疾病的潜在病原体。目前，MALDI-TOF和测序技术对其鉴定是必要的。
