Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Korea.
Ann Lab Med. 2012 Sep;32(5):375-9. doi: 10.3343/alm.2012.32.5.375. Epub 2012 Aug 13.
Schizophyllum commune, a basidiomycetous fungus, rarely causes disease in humans. We report a rare case of allergic fungal sinusitis caused by S. commune in a 14-yr-old girl. The patient presented with nasal obstruction and a purulent nasal discharge. Materials obtained during endoscopic surgery of the frontal recess revealed allergic mucin and a few fungal hyphae. A potato dextrose agar (PDA) culture from the allergic mucin yielded a rapidly growing white woolly mold. Although no distinctive features including hyphae bearing spicules or a clamp connection were present, the case isolate disclosed compatible mycological features including growth at 37℃, susceptibility to cycloheximide, and production of a tart and disagreeable smell. S. commune was confirmed by sequence analysis of the internal transcribed spacer region and D1/D2 regions of the 26S ribosomal DNA. We believe this is the first report of allergic fungal sinusitis caused by S. commune in Korea. Moreover, this report highlights the value of gene sequencing as an identification tool for non-sporulating isolates of S. commune.
栓菌，一种担子菌真菌，很少导致人类患病。我们报告了一例由栓菌引起的罕见变应性真菌性鼻旁窦炎病例，患者为 14 岁女孩。该患者表现为鼻塞和脓性鼻涕。内窥镜鼻窦手术中获得的材料显示有变应性粘蛋白和少量真菌菌丝。从变应性粘蛋白中进行的马铃薯葡萄糖琼脂（PDA）培养产生了一种快速生长的白色羊毛状霉菌。虽然没有发现特征性的结构，如带有刺的菌丝或夹状连接，但分离株显示出与其相符的微生物学特征，包括在 37℃下生长、对环丝氨酸敏感以及产生酸败和难闻的气味。通过对内部转录间隔区和 26S 核糖体 DNA 的 D1/D2 区进行序列分析，确认了栓菌的存在。我们认为这是首例在韩国由栓菌引起的变应性真菌性鼻旁窦炎病例。此外，该报告强调了基因测序作为鉴定非孢子形成的栓菌分离株的工具的价值。
