Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
J Am Acad Dermatol. 2020 Oct;83(4):1049-1056. doi: 10.1016/j.jaad.2020.04.158. Epub 2020 May 4.
Taller individuals are at higher risk of melanoma.
To prospectively investigate the association of height with nevus count and melanoma and estimate the proportion of height-melanoma association explained by nevus count among white participants from the Nurses' Health Study (NHS) and Nurses' Health Study 2 (NHS2).
We used Cox proportional hazards regression and multinomial logistic regression for data analyses, with adjustment of potential confounders in the multivariate model.
We included 82,468 and 106,069 women from NHS and NHS2, respectively. The hazard ratio was 1.21 (95% confidence interval [CI] 1.12-1.31) for the association between every 10-cm increase in height and melanoma. Compared with women with no nevi, the odds ratios (95% CIs) associated with a 10-cm increase in height were 1.35 (95% CI 1.23-1.48) in the NHS and 1.12 (95% CI 1.09-1.15) in the NHS2 for women with greater than or equal to 10 moles. The proportion of excess melanoma risk associated with each 10-cm increase in height explained by nevus count was 8.03% in the NHS and 10.22% in the NHS2.
Self-reported height and nevus count. Mole counts were limited to 1 arm or both legs.
Nevus count is an important explanatory factor for the excess risk of melanoma among taller white women.
高个子人群患黑色素瘤的风险更高。
前瞻性研究身高与痣数量和黑色素瘤的关系，并估计在来自护士健康研究（NHS）和护士健康研究 2 （NHS2）的白人参与者中，痣数量对身高-黑色素瘤关联的解释比例。
我们使用 Cox 比例风险回归和多项逻辑回归进行数据分析，并在多变量模型中调整潜在混杂因素。
我们分别纳入了 NHS 和 NHS2 中的 82468 名和 106069 名女性。身高每增加 10 厘米，与黑色素瘤的风险比为 1.21（95%置信区间[CI] 1.12-1.31）。与无痣的女性相比，NHS 中身高每增加 10 厘米的痣相关比值比（95%CI 1.35 [1.23-1.48]）和 NHS2 中身高每增加 10 厘米的痣相关比值比（95%CI 1.12 [1.09-1.15]）为 1.35（95%CI 1.23-1.48），痣数量大于或等于 10 个。NHS 中身高每增加 10 厘米所解释的黑色素瘤超额风险比例为 8.03%，NHS2 中为 10.22%。
自我报告的身高和痣数量。痣的数量仅限于 1 只手臂或双腿。
痣数量是白人高个子女性黑色素瘤超额风险的一个重要解释因素。
